Simple and Reliable Measurement of Nitric Oxide Metabolites in Plasma

作者: Han Moshage

DOI: 10.1373/CLINCHEM.2009.128710

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摘要: Featured article: Moshage H, Kok B, Huizenga JR, Jansen PLM. Nitrite and nitrate determinations in plasma: a critical evaluation. Clin Chem 1995;41: 892–6.1 The history of nitric oxide (NO•) is remarkable one. In the early 1980s it was established that produced human body. Shortly afterward became clear had important functions regulation vascular tone, demonstrated identical to endothelium-derived relaxing factor, factor derived from endothelial cells induced relaxation smooth muscle cells. Nitric selected as 1992 Molecule Year by journal Science , 1998 Nobel Prize for Medicine or Physiology awarded Louis Ignarro, Ferid Murad, Robert Furchgott, founders research. Since its discovery, gaseous radical has elicited much attention scientific community, been implicated many diverse processes ranging tone male erectile function neurotransmission microbiocidal activity. Soon …

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