Elevated circulating pigment epithelium-derived factor predicts the progression of diabetic nephropathy in patients with type 2 diabetes.
作者： Elaine Hui , Chun-Yip Yeung , Paul C.H. Lee , Yu-Cho Woo , Carol H.Y. Fong
DOI: 10.1210/JC.2014-2235
关键词:
摘要: Context: Pigment epithelium-derived factor (PEDF), a circulating glycoprotein with antiangiogenic, antioxidative, and anti-inflammatory properties, protects against diabetic nephropathy (DN) in animal models. Objective: We investigated whether PEDF predicted the progression of DN 4-year prospective study. Design, Setting, Participants: Baseline plasma levels were measured type 2 subjects recruited from Hong Kong West Diabetes Registry. The role predicting chronic kidney disease (CKD) albuminuria was analyzed using Cox regression analysis. Main Outcome Measure: evaluated CKD progression, defined as deterioration staging 25% or greater drop estimated glomerular filtration rate (eGFR) according to International Society Nephrology statements. Results: At baseline, increased progressively (P for trend <.001; n = 1136). Among 1071 baseline stage ≤3, ...
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