A cross-reactive idiotype on anti-DNA antibodies defines a H chain determinant present almost exclusively on IgG antibodies.

摘要: We have previously reported two anti-idiotypic antibodies, 3I and 8.12, that recognize L chain determinants on anti-DNA antibodies. generated a new antibody, F4, recognizes H determinant cationic F4 reactivity is present in high titer serum of approximately 60% SLE patients 84 706 myeloma proteins. It preferentially associated with reactive chains. Furthermore, antibodies bearing both the idiotypic bind DNA. Amino acid sequencing chains isolated from four F4-reactive proteins suggests they derive currently identified VH gene families. restricted almost exclusively to Ig IgG isotype suggesting may either somatically mutated hypervariable region or variable used late immune response. therefore, represents family auto-Ag specificity having features an Ag-driven