Idiotypic Analysis of Human Anti-Topoisomerase I Autoantibodies
作者： Sabine Hildebrandt , G. Stephen Noell , Dolores Vazquez-abad , William C. Earnshaw , Maurizio Zanetti
DOI: 10.3109/08916939108997146
关键词:
摘要: Anti-topoisomerase I autoantibodies (anti-topo I) are associated with proximal scleroderma and of prognostic significance in patients Raynaud's phenomenon. Polyclonal anti-idiotypic sera were raised against affinity-purified anti-topo from 2 (EM, SG) healthy individual (NM). All 3 preparations expressed immunodominant private Ids or near the antigen binding site autoantibody. Further analysis Id-EM showed isotypic restriction to IgG a stable Id-expression over course 9 years. Id-SG Id-NM on IgA. The idiotypic character closely resembles that anti-centromere which CREST syndrome scleroderma. data suggest an antigen-driven process origin
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