Proliferation markers and cell cycle inhibitors in pituitary adenomas.
作者： W. Saeger
DOI: 10.1159/000079040
关键词:
摘要: Proliferation markers are widely used in general surgical pathology and also pituitary pathology. They should help for differing aggressive or rapidly growing tumors from those with slower growth, as cellular atypia is not helpful identifying adenomas of the pituitary. Only number mitoses important prognosis. A lot can be used: antibodies cyclins A, B, D E, proliferating cell nuclear antigen, Ki-67/Mib-1, inhibitory proteins p16, p27, p53, DNA topoisomerase IIalpha. marker apoptosis its inhibitors may important. From our experiences, Mib-1 most reliable marker. The recommendation this WHO classification fully justified.
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