Membrane transport of vanadium compounds and the interaction with the erythrocyte membrane

摘要: In the present work, membrane transport and biotransformation of vanadate, bis(maltolato)oxovanadium (VO(ma)2), vanadyl acetylacetonate (VO(acac)2) were investigated to explore relationship with their insulin-like activity. Cellular uptake kinetics performed by ICP-AES EPR. The VO(acac)2 VO(ma)2 human erythrocytes showed intracellular vanadium level higher than NaVO3 these two complexes was presumed be via passive diffusion mechanism. A fraction oxidized anionic vanadium(V) species also entered cells anion channel. stability oxidation in erythrocyte vesicles using found more sensitive aqueous buffer solution. However, presence vesicles, retarded differences between them became insignificant. Thus, lifetime might prolonged physiological fluids. interaction membranes appears important stabilization complexes. Meanwhile, structural changes proteins observed. observed attribute insulin-mimetic mechanisms toxicities.