Synthesis, characterisation and DNA intercalation studies of regioisomers of ruthenium (II) polypyridyl complexes.

摘要: Abstract Regioisomers of the functional group main ligand (L) on a series [Ru(phen) 2 L] 2+ and [Ru(bpy) complexes, where phen is 1,10 phenanthroline bpy 2,2′-bipyridine, were synthesised to investigate interaction with deoxyribonucleic acid (DNA) as potential therapeutics. UV–Vis binding titrations, thermal denaturation circular dichroism used evaluate their DNA. The conclusions indicated significance auxiliary ligand; especially 1,10-phenanthroline has constants (K b ). systematic variation ligand(phen or bpy), polypyridyl (4-(1H-Imidazo[4,5-f][1,10]phenanthrolin-2-yl)benzonitrile (CPIP), 2-(4-formylphenyl)imidazo[4,5-f] [1,10] (FPIP), 2-(4-bromophenyl)imidazo[4,5-f][1,10]phenanthroline (BPIP) 2-(4-nitrophenyl)imidazo[4,5-f] (NPIP), split in terms change investigated for DNA interaction. CPIP analogues particular regioisomerism ( ortho , meta para ) effect nitrile ligand. It was found that both could be tailored through electronic nature individual lesser extent regioisomeric change. Preliminary cell line studies have been carried out determine selectivity complexes against lines such A375 (Skin Cancer), HeLa (Cervical A549 (Lung Beas2B Normal Cell) MCF-7 (Breast Cancer). Complexes which had strong interactions proven most efficacious certain lines. Establishing well-defined structure property relationships when looking at trends spectroscopic properties will aid intelligent design therapeutic complexes.