Brain Capillary Tissue Plasminogen Activator in a Diabetes Stroke Model
作者： Mamoru Kittaka , Liang Wang , Ning Sun , Steven S. Schreiber , Nicholas W. Seeds
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摘要: Background and Purpose Tissue plasminogen activator (TPA) is normally expressed in rat brain capillaries. This study examines the expression of TPA capillaries diabetic rats relation to focal ischemic injury. Methods Diabetes type 1 was induced by streptozotocin for 7 days. Acute hyperglycemia 50% dextrose. Expression determined Western blot reverse transcription-polymerase chain reaction analyses. Focal stroke produced hour reversible middle cerebral artery occlusion. Physiological variables blood flow were monitored during occlusion within reperfusion. Neurological neuropathologic examinations performed after 24 hours Results All developed comparable (≈15 mmol/L). A complete depletion protein 6.5-fold decrease mRNA found rats, contrast normal capillary levels hyperglycemic rats. T...
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