T-lymphocyte maturation abnormalities in uninfected newborns and children with vertical exposure to HIV

摘要: Cell-mediated immunity and T-lymphocyte maturation are impaired in HIV-infected children. These abnormalities would be detected HIV-uninfected offspring of HIV women (seroreverters [SR]) if or its soluble proteins could cross the placental barrier. Immunophenotypic analyses were performed 20 healthy newborns mothers (SR), 14 HIV-negative (UC). The same 3 groups older children: SR (n = 41); UC 15); children 25). Antigen-specific cells evaluated with ELISpot fluorimetric analyses; IL-7 serum concentration was measured by enzyme-linked immunosorbent assay (ELISA). Results showed that newborns: (1) CD4/CD8 ratio reduced, (2) CD4(+) CD8(+) naive T-cell percentages decreased, (3) percentage activated T increased, (4) CD3(+)/4(-)/8(-) (DN) DN/25(-)/44(+) augmented. partially retained HIV-specific a portion newborn SRs but not SRs. Serum augmented both altered even mothers; these persist over time. biologic significance observations potential subsequent clinical events should investigated larger cohorts seroreverters. (Blood. 2000;96:3866-3871)