Hyphenated techniques as tools for speciation analysis of metal-based pharmaceuticals: developments and applications
作者： Björn Meermann , Michael Sperling
DOI: 10.1007/S00216-012-5915-9
关键词:
摘要: Method development and applications of hyphenated techniques as tools for speciation analysis metal-based pharmaceuticals are summarized within this review. Advantages limitations the separation modes—high-performance liquid chromatography (HPLC), capillary electrophoresis (CE), gas (GC)—as well detection modes—inductively coupled plasma–mass spectrometry (ICP-MS) electrospray ionization–mass (ESI-MS)—are discussed. ICP-MS is found to be advantageous quantification drugs containing metals other heteroatoms. The species-independent sensitivity multielement capabilities allow it used even when species-specific standards not available, determine stoichiometry in metallodrug–biomolecule interactions. Molecular information that totally destroyed ICP applied ionization source therefore obtainable via can accessed by complementary technique ESI-MS. Speciation combining both elemental molecular a powerful tool their metabolites body fluids relevant matrices.
springer.com
sci-hub.se 参考文章(178)
Robert A Parise, Dale R Miles, Merrill J Egorin, Sensitive high-performance liquid chromatographic assay for motexafin gadolinium and motexafin lutetium in human plasma. Journal of Chromatography B: Biomedical Sciences and Applications. ,vol. 749, pp. 145- 152 ,(2000) , 10.1016/S0378-4347(00)00390-X
Frank Sacher, Brigitte Raue, Heinz-Jürgen Brauch, Analysis of iodinated X-ray contrast agents in water samples by ion chromatography and inductively-coupled plasma mass spectrometry. Journal of Chromatography A. ,vol. 1085, pp. 117- 123 ,(2005) , 10.1016/J.CHROMA.2005.01.031
Hua-Bin Li, Feng Chen, None, Determination of vitamin B12 in pharmaceutical preparations by a highly sensitive fluorimetric method. Fresenius Journal of Analytical Chemistry. ,vol. 368, pp. 836- 838 ,(2000) , 10.1007/S002160000595
Osmond J. D'Cruz, Fatih M. Uckun, Intravaginal Toxicity Studies of a Gel-Microemulsion Formulation of Spermicidal Vanadocenes in Rabbits Toxicology and Applied Pharmacology. ,vol. 170, pp. 104- 112 ,(2001) , 10.1006/TAAP.2000.9089
V�ronique Vacchina, Laura Torti, Cecilia Allievi, Ryszard Lobinski, Sensitive species-specific monitoring of a new triplatinum anti-cancer drug and its potential related compounds in spiked human plasma by cation-exchange HPLC-ICP-MS Journal of Analytical Atomic Spectrometry. ,vol. 18, pp. 884- 890 ,(2003) , 10.1039/B302241B
Katharina Lenz, Stephan Hann, Gunda Koellensperger, Zsolt Stefanka, Gerhard Stingeder, Norbert Weissenbacher, Susanne N. Mahnik, Maria Fuerhacker, Presence of cancerostatic platinum compounds in hospital wastewater and possible elimination by adsorption to activated sludge. Science of The Total Environment. ,vol. 345, pp. 141- 152 ,(2005) , 10.1016/J.SCITOTENV.2004.11.007
Kasia Polec-Pawlak, Jan K. Abramski, Olga Semenova, Christian G. Hartinger, Andrei R. Timerbaev, Bernhard K. Keppler, Maciej Jarosz, Platinum group metallodrug-protein binding studies by capillary electrophoresis - inductively coupled plasma-mass spectrometry: a further insight into the reactivity of a novel antitumor ruthenium(III) complex toward human serum proteins. Electrophoresis. ,vol. 27, pp. 1128- 1135 ,(2006) , 10.1002/ELPS.200500694
Alexei Makarov, Joanna Szpunar, Species-selective determination of cobalamin analogues by reversed-phase HPLC with ICP-MS detection Journal of Analytical Atomic Spectrometry. ,vol. 14, pp. 1323- 1327 ,(1999) , 10.1039/A900633H
Zhongwen Wang, Jin Zhou, Xiufen Lu, Zhilong Gong, X. Chris Le, Arsenic speciation in urine from acute promyelocytic leukemia patients undergoing arsenic trioxide treatment Chemical Research in Toxicology. ,vol. 17, pp. 95- 103 ,(2004) , 10.1021/TX0341714
Susan J. Berners-Price, Aleksandra Filipovska, Gold compounds as therapeutic agents for human diseases Metallomics. ,vol. 3, pp. 863- 873 ,(2011) , 10.1039/C1MT00062D