The human homolog T of the mouse T(Brachyury) gene; gene structure, cDNA sequence, and assignment to chromosome 6q27.
作者： Y H Edwards , W Putt , K M Lekoape , D Stott , M Fox
DOI: 10.1101/GR.6.3.226
关键词:
摘要: We have cloned the human gene encoding transcription factor T. T protein is vital for formation of posterior mesoderm and axial development in all vertebrates. Brachyury mutant mice, which lack protein, die utero with abnormal notochord, somites, allantois. identified genomic clones derived mRNA sequence structure. There 91% amino acid identity between mouse proteins overall complete across 77 acids T-box motif within DNA-binding domain. Human expression very similar to that found other vertebrate species confined cells from notochord. The maps chromosome 6q27 only second member family be described.
genome.org参考文章(33)
Yamakawa K, Nakamura Y, Hikiji K, Morita R, Tumor suppressor genes associated with development of human renal cell carcinoma Nihon rinsho. Japanese journal of clinical medicine. ,vol. 50, pp. 3100- ,(1992)
A. Kispert, B. Koschorz, B. G. Herrmann, The T protein encoded by Brachyury is a tissue‐specific transcription factor. The EMBO Journal. ,vol. 14, pp. 4763- 4772 ,(1995) , 10.1002/J.1460-2075.1995.TB00158.X
A. Kispert, B.G. Herrmann, The Brachyury gene encodes a novel DNA binding protein. The EMBO Journal. ,vol. 12, pp. 3211- 3220 ,(1993) , 10.1002/J.1460-2075.1993.TB05990.X
Valerie Wilson, P Rashbass, R S Beddington, Brachyury--a gene affecting mouse gastrulation and early organogenesis. Development. ,vol. 116, pp. 157- 165 ,(1992)
Valerie Wilson, P Rashbass, R S Beddington, Chimeric analysis of T (Brachyury) gene function Development. ,vol. 117, pp. 1321- 1331 ,(1993) , 10.1242/DEV.117.4.1321
Marnie E. Halpern, Robert K. Ho, Charline Walker, Charles B. Kimmel, Induction of muscle pioneers and floor plate is distinguished by the zebrafish no tail mutation Cell. ,vol. 75, pp. 99- 111 ,(1993) , 10.1016/S0092-8674(05)80087-X
G. O. Pflugfelder, H. Roth, B. Poeck, S. Kerscher, H. Schwarz, B. Jonschker, M. Heisenberg, The Lethal(1) Optomotor-Blind Gene of Drosophila melanogaster is a Major Organizer of Optic Lobe Development: Isolation and Characterization of the Gene Proceedings of the National Academy of Sciences of the United States of America. ,vol. 89, pp. 1199- 1203 ,(1992) , 10.1073/PNAS.89.4.1199
Andreas Kispert, Hubert Ortner, Jonathan Cooke, Bernhard G. Herrmann, The Chick Brachyury Gene: Developmental Expression Pattern and Response to Axial Induction by Localized Activin Developmental Biology. ,vol. 168, pp. 406- 415 ,(1995) , 10.1006/DBIO.1995.1090
V Orphanos, G McGown, Y Hey, M Thorncroft, M Santibanez-Koref, SEH Russell, I Hickey, RJ Atkinson, JM Boyle, Allelic imbalance of chromosome 6q in ovarian tumours British Journal of Cancer. ,vol. 71, pp. 666- 669 ,(1995) , 10.1038/BJC.1995.132
Yvonne H. Edwards, Wendy Putt, Margaret Fox, Jane H. Ives, A novel human phosphoglucomutase (PGM5) maps to the centromeric region of chromosome 9. Genomics. ,vol. 30, pp. 350- 353 ,(1995) , 10.1006/GENO.1995.9866