O1‐10‐03: ANATOMICAL STAGING OF BETA‐AMYLOID ACCUMULATION BASED ON LONGITUDINAL ASSESSMENT OF GLOBALLY PIB NEGATIVE ADULTS

摘要: BackgroundAnatomical staging of amyloid accumulation has thus far largely relied on cross-sectional PIB and autopsy data. The present study sought to instead derive anatomical staging from the spatiotemporal dynamics of amyloid using longitudinal PIB data. We examined initially global PIB-adults, to focus on identifying a subset of early-accumulating (Stage-1) regions which exhibit slight baseline regional elevations that predict subsequent global changes in amyloid, and later-accumulating (Stage-2) regions that were not predictive of change but were themselves changing. Regions not yet predictive of change nor changing in global PIB-adults were presumed to be latest-accumulating (Stage-3).Methods265 clinically-normal individuals were included from the Harvard Aging Brain Study (median follow-up= 3.24 (1.27) years, age 62-91, global PIB-n= 193). Half of the baseline global PIB-adults (n= 96) were …