Serine threonine kinase (AKT) degradation/disruption compounds and methods of use

摘要: 0* C1 ([4*]) CC ([3*]) c2c (B3CC*([Y] C ([1*]) CCC (C)(C) C) CC3 [2*]) ccnc21 Chemical compound* C1 ([4*]) CC ([3*]) c2c (B3CC*([Y] C ([1*]) CCC (C)(C) C) CC3 [2*]) ccnc21 0.000 description 53UVVLXWHHQILFQF-WWJGCAJLSA-N CC (C)(C) C. CC (C)(C) OCC [C@ H](NC (= O) C1 (N) CCN (c2ncnc3 [nH] ccc23) CC1) c1ccc (Cl) cc1. CCn1c (-c2nonc2N) nc2c (C# CC (C)(C) O) ncc (OC [C@ H] 3CCCNC3) c21. C [C@@ H] 1C [C@@ H](O) c2ncnc (N3CCN (C (= O)[C@ H](CCC (C)(C) C) c4ccc (Cl) cc4) CC3) c21. Cn1ncc (Cl) c1-c1cc (C (= O) CC (CNC (C)(C) C) Cc2ccc (F) c (F) c2) oc1Cl. Cn1ncc (Cl) c1-c1cc (C (= O) C [C@ H](CNC (C)(C) C) Cc2ccc (F) c (F) c2) sc1Cl Chemical compound CC (C)(C) C. CC (C)(C) OCC [C@ H](NC (= O) C1 (N) CCN (c2ncnc3 [nH] ccc23) CC1) c1ccc (Cl) cc1. CCn1c (-c2nonc2N) nc2c (C# CC (C)(C) O) ncc (OC [C@ H] 3CCCNC3) c21. C [C@@ H] 1C [C@@ H](O) c2ncnc (N3CCN …