Paul Watkins
机构: Professor of Pharmacy, Medicine and Public Health University of North Carolina, Chapel Hill
每年引用次数
引用次数
引用: 43,883
H-指数: 104
I10-指数 : 280
出版物: 498
Identification of a human liver cytochrome P-450 homologous to the major isosafrole-inducible cytochrome P-450 in the rat.
J E Shively , S A Wrighton , P B Watkins , W Levin
Molecular Pharmacology 29 ( 4) 405 -410
99
1986
Identification of a polymorphically expressed member of the human cytochrome P-450III family.
M VandenBranden , B J Ring , S A Wrighton , P B Watkins
Molecular Pharmacology 36 ( 1) 97 -105
215
1989
Interpatient heterogeneity in expression of CYP3A4 and CYP3A5 in small bowel. Lack of prediction by the erythromycin breath test.
K S Lown , S A Wrighton , P B Watkins , J C Kolars
Drug Metabolism and Disposition 22 ( 6) 947 -955
327
1994
Metabolism of the immunosuppressant tacrolimus in the small intestine: cytochrome P450, drug interactions, and interindividual variability
U Christians , A Bader , F P Guengerich , P B Watkins
Drug Metabolism and Disposition 23 ( 12) 1315 -1324
331
1995
Demonstration in multiple species of inducible hepatic cytochromes P-450 and their mRNAs related to the glucocorticoid-inducible cytochrome P-450 of the rat.
P Guzelian , E G Schuetz , P Maurel , S A Wrighton
Molecular Pharmacology 28 ( 3) 312 -321
183
1985
Bimodal distribution of renal cytochrome P450 3A activity in humans
P B Watkins , S D Hall , B D Haehner , J C Gorski
Molecular Pharmacology 50 ( 1) 52 -59
235
1996
Blood gene expression profiling of an early acetaminophen response.
P R Bushel , R D Fannin , K Gerrish , P B Watkins
Pharmacogenomics Journal 17 ( 3) 230 -236
7
2017
Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man.
P B Watkins , S A Wrighton , E G Schuetz , D T Molowa
Journal of Clinical Investigation 80 ( 4) 1029 -1036
445
1987
Purification of a human liver cytochrome P-450 immunochemically related to several cytochromes P-450 purified from untreated rats.
S A Wrighton , P E Thomas , P Willis , S L Maines
Journal of Clinical Investigation 80 ( 4) 1017 -1022
57
1987
Erythromycin breath test as an assay of glucocorticoid-inducible liver cytochromes P-450. Studies in rats and patients.
P B Watkins , S A Murray , L G Winkelman , D M Heuman
Journal of Clinical Investigation 83 ( 2) 688 -697
304
1989
The caffeine breath test does not identify patients susceptible to tacrine hepatotoxicity
R J Fontana , D K Turgeon , T F Woolf , M J Knapp
Hepatology 23 ( 6) 1429 -1435
18
1996
Identification of rifampin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes.
J C Kolars , P Schmiedlin-Ren , J D Schuetz , C Fang
Journal of Clinical Investigation 90 ( 5) 1871 -1878
508
1992
Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression.
K S Lown , D G Bailey , R J Fontana , S K Janardan
Journal of Clinical Investigation 99 ( 10) 2545 -2553
546
1997
Induction of digitoxigenin monodigitoxoside UDP-glucuronosyltransferase activity by glucocorticoids and other inducers of cytochrome P-450p in primary monolayer cultures of adult rat hepatocytes and in human liver.
E G Schuetz , G A Hazelton , J Hall , P B Watkins
Journal of Biological Chemistry 261 ( 18) 8270 -8275
48
1986
Macrolide antibiotics inhibit the degradation of the glucocorticoid-responsive cytochrome P-450p in rat hepatocytes in vivo and in primary monolayer culture.
P B Watkins , S A Wrighton , E G Schuetz , P Maurel
Journal of Biological Chemistry 261 ( 14) 6264 -6271
153
1986
Nocturnal Augmentation of Growth Hormone (GH) Secretion Is Preserved during Repetitive Bolus Administration of GH-Releasing Hormone: Potential Involvement of Endogenous Somatostatin-A Clinical Research Center Study*
C A Jaffe , D K Turgeon , R D Friberg , P B Watkins
The Journal of Clinical Endocrinology and Metabolism 80 ( 11) 3321 -3326
49
1995
Use of Pharmaco‐Metabonomics for Early Prediction of Acetaminophen‐Induced Hepatotoxicity in Humans
J H Winnike , Z Li , F A Wright , J M Macdonald
Clinical Pharmacology & Therapeutics 88 ( 1) 45 -51
161
2010
Managing the risk of drug-induced liver injury.
P B Watkins
Clinical Pharmacology & Therapeutics 94 ( 6) 629 -631
9
2013
Systems Pharmacology Modeling Predicts Delayed Presentation and Species Differences in Bile Acid–Mediated Troglitazone Hepatotoxicity
K Yang , J L Woodhead , P B Watkins , B A Howell
Clinical Pharmacology & Therapeutics 96 ( 5) 589 -598
65
2014
The application of metabonomics to predict drug-induced liver injury.
T M O'Connell , P B Watkins
Clinical Pharmacology & Therapeutics 88 ( 3) 394 -399
53
2010