Andreas Kraemer
机构: Group Leader, Structural Genomics Consortium
每年引用次数
引用次数
引用: 921
H-指数: 16
I10-指数 : 21
出版物: 56
Tracking the PROTAC degradation pathway in living cells highlights the importance of ternary complex measurement for PROTAC optimization
Martin P Schwalm , Andreas Krämer , Anja Dölle , Janik Weckesser
Cell Chemical Biology
2023
Shifting the selectivity of pyrido [2, 3-d] pyrimidin-7 (8H)-one inhibitors towards the salt-inducible kinase (SIK) subfamily
Marcel Rak , Roberta Tesch , Lena M Berger , Ekaterina Shevchenko
European Journal of Medicinal Chemistry 254 115347 -115347
5
2023
Back-pocket optimization of 2-aminopyrimidine-based macrocycles leads to potent dual EPHA2/GAK kinase inhibitors with antiviral activity
Joshua Gerninghaus , Rezart Zhubi , Andreas Kraemer , Marwah Karim
bioRxiv
2024
Structural basis of p53 inactivation by cavity-creating cancer mutations and its implications for the development of mutant p53 reactivators
Dimitrios-Ilias Balourdas , Anja M Markl , Andreas Krämer , Giovanni Settanni
Cell Death & Disease 15 ( 6) 408 -408
2024
Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress
Nadilly Bonagas , Nina MS Gustafsson , Martin Henriksson , Petra Marttila
Nature Cancer 156 -172
36
2022
Chemistry-led investigations into the mode of action of NAMPT activators, resulting in the discovery of non-pyridyl class NAMPT activators
Siyuan Tang , Miguel Garzon Sanz , Oliver Smith , Andreas Krämer
Acta Pharmaceutica Sinica B 13 ( 2) 709 -721
10
2023
Function, structure and topology of protein kinases
Sandra Röhm , Andreas Krämer , Stefan Knapp
Proteinkinase Inhibitors 1 -24
8
2021
Discovery of potent Plasmodium falciparum protein kinase 6 (PfPK6) inhibitors with a type II inhibitor pharmacophore
Han Wee Ong , Anna Truong , Frank Kwarcinski , Chandi de Silva
European Journal of Medicinal Chemistry 249 115043 -115043
7
2023
Aurora kinase A Is involved in controlling the localization of Aquaporin-2 in renal principal cells
Sandrine Baltzer , Timur Bulatov , Christopher Schmied , Andreas Krämer
International Journal of Molecular Sciences 23 ( 2) 763 -763
5
2022
Discovery of 3-Amino-1 H-pyrazole-Based Kinase Inhibitors to Illuminate the Understudied PCTAIRE Family
Jennifer Alisa Amrhein , Lena Marie Berger , Amelie Tjaden , Andreas Krämer
International Journal of Molecular Sciences 23 ( 23) 14834 -14834
3
2022
Synthesis and biological evaluation of 1H-pyrrolo [3, 2–g] isoquinolines
Mathilde Defois , Béatrice Josselin , Pierre Brindeau , Andreas Krämer
Bioorganic & Medicinal Chemistry 100 117619 -117619
1
2024
Synthesis and Biological Evaluation of 2-Substituted Quinazolin-4 (3 H)-Ones with Antiproliferative Activities
Maria Karelou , Dionysis Kampasis , Amalia D Kalampaliki , Leentje Persoons
Molecules 28 ( 23) 7912 -7912
1
2023
Synthesis and evaluation of chemical linchpins for highly selective CK2α targeting
Francesco A Greco , Andreas Krämer , Laurenz Wahl , Lewis Elson
European journal of medicinal chemistry 276 116672 -116672
1
2024
Elimination of mutant SWI/SNF complexes by protein quality control: new opportunities targeting aggressive rhabdoid tumours
Andreas Krämer , Stefan Knapp
Signal Transduction and Targeted Therapy 9 ( 1) 224 -224
2024
Strategic Fluorination to Achieve a Potent, Selective, Metabolically Stable, and Orally Bioavailable Inhibitor of CSNK2
Han Wee Ong , Xuan Yang , Jeffery L Smith , Sharon Taft-Benz
Molecules 29 ( 17) 4158 -4158
2024
Cascade Synthesis of Kinase-Privileged 3-Aminoindazoles via Intramolecular N--N Bond Formation
W Felix Zhu , Andreas Krämer , Stefan Knapp , Ewgenij Proschak
The Journal of Organic Chemistry 87 ( 5) 3856 -3862
1
2022
Macrocyclization of quinazoline-based EGFR inhibitors leads to exclusive mutant selectivity for EGFR L858R and Del19
Jennifer A Amrhein , Tyler S Beyett , William W Feng , Andreas Krämer
Journal of Medicinal Chemistry 65 ( 23) 15679 -15697
2022
Leucettinibs, a Class of DYRK/CLK Kinase Inhibitors Inspired by the Marine Sponge Natural Product Leucettamine B
Emmanuel Deau , Mattias F Lindberg , Frédéric Miege , Didier Roche
Journal of Medicinal Chemistry 66 ( 15) 10694 -10714
4
2023
Chemical, Biochemical, Cellular, and Physiological Characterization of Leucettinib-21, a Down Syndrome and Alzheimer’s Disease Drug Candidate
Mattias F Lindberg , Emmanuel Deau , Frédéric Miege , Marie Greverie
Journal of Medicinal Chemistry 66 ( 23) 15648 -15670
1
2023
Synthesis of pyrazole-based macrocycles leads to a highly selective inhibitor for MST3
Jennifer Alisa Amrhein , Lena Marie Berger , Dimitrios-Ilias Balourdas , Andreas C Joerger
Journal of Medicinal Chemistry 67 ( 1) 674 -690
1
2023
Stefan Knapp Andreas C. Joerger Franz-Josef Meyer-Almes Benedict-Tilman Berger Cheryl Arrowsmith David Heidenreich Claire E. Weston Matthias Baud Christian Meyners Oleg Fedorov Masoud Vedadi Qin Wu Dr. Stanley Zhou, PhD Mathieu Lupien, Ph.D. Kiran Nakka S Ackloo Panagis Filippakopoulos Genevieve Deblois Alan Fersht John Spencer