Defining Diverse Disease Pathomechanisms Across Thick And Thin Filament Hypertrophic Cardiomyopathy Variants.

Christopher Toepfer , Yiangos Psaras , Francesca Margara , Manuel Schmid
Circulation Research 129 ( Suppl_1) A402 -A402

2
2021
General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy

Zhihua Li , Gary R Mirams , Takashi Yoshinaga , Bradley J Ridder
Clinical Pharmacology & Therapeutics 107 ( 1) 102 -111

32
2020
Drug-induced shortening of the electromechanical window is an effective biomarker for in silico prediction of clinical risk of arrhythmias.

Elisa Passini , Cristian Trovato , Pierre Morissette , Frederick Sannajust
British Journal of Pharmacology 176 ( 19) 3819 -3833

16
2019
What determines the optimal pharmacological treatment of atrial fibrillation? Insights from in silico trials in 800 virtual atria

Albert Dasí , Michael TB Pope , Rohan S Wijesurendra , Tim R Betts
The Journal of Physiology 601 ( 18) 4013 -4032

4
2023
Fractional diffusion models of cardiac electrical propagation

Bueno-Orovio , Alfonso and Kay , David and Grau , Vicente and Rodriguez
Smpte Journal

1
2014
2017
2018
Probabilistic Computational Assessment of Arrhythmic Risk in Post-Myocardial Infarction Human Ventricles

Alfonso Bueno-Orovio , Mikael Wallman , Blanca Rodriguez
In proceedings of Heart Rhythm 35th Annual Scientific Session

2014
Population of human ventricular cell models calibrated with in vivo measurements unravels ionic mechanisms of cardiac alternans

Michele Orini , Alfonso Bueno-Orovio , Kevin Burrage , Pier D. Lambiase
computing in cardiology conference 855 -858

5
2013
Computational probabilistic quantification of pro-arrhythmic risk from scar and left-to-right heterogeneity in the human ventricles

Alfonso Bueno-Orovio , Mikael Wallman , Blanca Rodriguez
computing in cardiology conference 711 -714

2
2013
Effect of inter-subject variability in determining response to IKr block in human ventricular myocytes

Alfonso Bueno-Orovio , Oliver J Britton , Blanca Rodriguez , Laszlo Virag
computing in cardiology conference 41 869 -872

3
2014
Late sodium current inhibition counteracts pro-arrhythmic mechanisms in human hypertrophic cardiomyopathy

Elisabetta Cerbai , Alfonso Bueno-Orovio , Stefano Severi , Elisa Passini
computing in cardiology conference 41 861 -864

2014
A computational investigation into the effect of infarction on clinical human electrophysiology biomarkers

Louie Cardone-Noott , Alfonso Bueno-Orovio , Ana Minchole , Kevin Burrage
computing in cardiology conference 41 673 -676

2
2014
Toward a broader view of mechanisms of drug cardiotoxicity.

Alfonso Bueno-Orovio , Blanca Rodriguez , Polina Mamoshina
Cell reports. Medicine 2 ( 3) 100216 -100216

29
2021
CalTrack: High Throughput Automated Calcium Transient Analysis in Cardiomyocytes.

Alfonso Bueno-Orovio , Marcelo Cicconet , Jonathan G Seidman , Christine E Seidman
Circulation Research

2021
Electrophysiological and Contractile Effects of Disopyramide in Patients With Obstructive Hypertrophic Cardiomyopathy: A Translational Study.

Leonardo Sacconi , Pierluigi Stefàno , Laura Flink , Katherine Riedy
JACC: Basic to Translational Science 4 ( 7) 795 -813

10
2019
Loss of Myocardial nNOS Mediated by Upregulation of miR-31 in Human Atria Contributes to Begetting of Atrial Fibrillation

Xing Liu , Svetlana Reilly , Ricardo Carnicer , Alice Recalde
Biophysical Journal 110 ( 3) 451a

2016
Spectral smoothed boundary methods: The role of external boundary conditions

Alfonso Bueno-Orovio , Víctor M. Pérez-García
Numerical Methods for Partial Differential Equations 22 ( 2) 435 -448

41
2006
Anomalous Diffusion in Cardiac Tissue as an Index of Myocardial Microstructure

Alfonso Bueno-Orovio , Irvin Teh , Jurgen E. Schneider , Kevin Burrage
IEEE Transactions on Medical Imaging 35 ( 9) 2200 -2207

22
2016
Fourier spectral methods for fractional-in-space reaction-diffusion equations

Alfonso Bueno-Orovio , David Kay , Kevin Burrage
Bit Numerical Mathematics 54 ( 4) 937 -954

316
2014