Using CRISPR to understand and manipulate gene regulation.

Richard I Sherwood , Ersin Akinci , Ersin Akinci , Benyapa Khowpinitchai
Development 148 ( 9)

2021
High-throughput mapping of regulatory DNA

Nisha Rajagopal , Sharanya Srinivasan , Kameron Kooshesh , Yuchun Guo
Nature Biotechnology 34 ( 2) 167 -174

162
2016
Discovery of directional and nondirectional pioneer transcription factors by modeling DNase profile magnitude and shape

Richard I Sherwood , Tatsunori Hashimoto , Charles W O'Donnell , Sophia Lewis
Nature Biotechnology 32 ( 2) 171 -178

349
2014
Small molecule inhibition of ATM kinase increases CRISPR-Cas9 1-bp insertion frequency

Heysol C Bermudez-Cabrera , Sannie Culbertson , Sammy Barkal , Benjamin Holmes
Nature communications 12 ( 1) 5111

10
2021
Peptide fusion improves prime editing efficiency

Minja Velimirovic , Larissa C Zanetti , Max W Shen , James D Fife
Nature Communications 13 ( 1) 3512

13
2022
A molecular glue approach to control the half-life of CRISPR-based technologies

Vedagopuram Sreekanth , Max Jan , Kevin T Zhao , Donghyun Lim
bioRxiv

3
2023
Little Evidence for Developmental Plasticity of Adult Hematopoietic Stem Cells

Amy J Wagers , Richard I Sherwood , Julie L Christensen , Irving L Weissman
Science 297 ( 5590) 2256 -2259

1,911
2002
Adult Hematopoietic Stem Cells

Amy J Wagers , Richard I Sherwood , Julie L Christensen , Irving L Weissman
Emerg. Infect. Dis 3 295 -295

1997
66
2012
Joint genotypic and phenotypic outcome modeling improves base editing variant effect quantification

Jayoung Ryu , Sam Barkal , Tian Yu , Martin Jankowiak
Nature Genetics 1 -13

2
2024
Systematic elucidation of genetic mechanisms underlying cholesterol uptake

Marisa C Hamilton , James D Fife , Ersin Akinci , Tian Yu
Cell Genomics 3 ( 5)

5
2023
Predictable and precise template-free CRISPR editing of pathogenic variants (vol 563, pg 646, 2018)

Max W Shen , Mandana Arbab , Jonathan Y Hsu , Daniel Worstell
Nature 567 ( 7746) E1 -E2

1
2019
High-Throughput Investigation of Human Genes and Variants Affecting LDL Cholesterol Uptake

Marisa C Hamilton , James D Fife , Minsun Cha , Christopher A Cassa
Circulation 144 ( Suppl_1) A13554 -A13554

2021
Outstanding questions

Richard I Sherwood , Amy J Wagers
Trends in Molecular Medicine 5 ( 12) 189 -192

2006
Transcriptional dynamics of endodermal organ formation.

Richard I Sherwood , Tzong‐Yang Albert Chen , Douglas A Melton ,
Developmental Dynamics 238 ( 1) 29 -42

170
2009
Prostaglandin E2 Regulates Liver versus Pancreas Cell-Fate Decisions and Endodermal Outgrowth

Sahar Nissim , Richard I. Sherwood , Julia Wucherpfennig , Diane Saunders
Developmental Cell 28 ( 4) 423 -437

32
2014
Detection of gene cis-regulatory element perturbations in single-cell transcriptomes

David K. Gifford , Richard I. Sherwood , Budhaditya Banerjee , Max W. Shen
PLOS Computational Biology 17 ( 3)

2021
A CRISPR view of gene regulation

Budhaditya Banerjee , Richard I. Sherwood
Current Opinion in Systems Biology 1 1 -8

10
2017
Determinants of Skeletal Muscle Contributions from Circulating Cells, Bone Marrow Cells, and Hematopoietic Stem Cells

Richard I. Sherwood , Julie L. Christensen , Irving L. Weissman , Amy J. Wagers
Stem Cells 22 ( 7) 1292 -1304

85
2004