Richard A. Engh
机构: Professor of Chemistry, UiT the Arctic University of Norway
每年引用次数
引用次数
引用: 13,111
H-指数: 50
I10-指数 : 101
出版物: 188
Domain truncation, point mutation, and surrogation for structure based kinase inhibitor design
D Bossemeyer , C B Breitenlechner , M Gassel , R A Engh
Cellular & Molecular Biology Letters 10
2005
The low frequency of clinical resistance to PDGFR inhibitors in myeloid neoplasms with abnormalities of PDGFRA might be related to the limited repertoire of possible PDGFRA kinase domain mutations in vitro
N von Bubnoff , S P Gorantla , R A Engh , T M Oliveira
Oncogene 30 ( 8) 933 -943
27
2011
Dynamics of the emergence of dasatinib and nilotinib resistance in imatinib-resistant CML patients.
F X Gruber , T Ernst , K Porkka , R A Engh
Leukemia 26 ( 1) 172 -177
34
2012
Diversity of bisubstrate binding modes of adenosine analogue-oligoarginine conjugates in protein kinase a and implications for protein substrate interactions.
Alexander Pflug , Jevgenia Rogozina , Darja Lavogina , Erki Enkvist
Journal of Molecular Biology 403 ( 1) 66 -77
22
2010
Probing the ATP-Binding Pocket of Protein Kinase Dyrk1A with Benzothiazole Fragment Molecules
Ulli Rothweiler , Wenche Stensen , Bjørn Olav Brandsdal , Johan Isaksson
Journal of Medicinal Chemistry 59 ( 21) 9814 -9824
14
2016
Bifunctional Ligands for Inhibition of Tight-Binding Protein–Protein Interactions
Taavi Ivan , Erki Enkvist , Birgit Viira , Ganesh babu Manoharan
Bioconjugate Chemistry 27 ( 8) 1900 -1910
11
2016
Biofocussed chemoprospecting: An efficient approach for drug discovery
Balmukund Sureshkumar Thakkar , Marte Albrigtsen , John Sigurd Svendsen , Jeanette H Andersen
Chemical Biology & Drug Design 90 ( 1) 128 -140
1
2017
Novel scaffolds for Dual specificity tyrosine-phosphorylation-regulated kinase (DYRK1A) inhibitors
Anna Czarna , Jinhua Wang , Diana Zelencova , Yao Liu
Journal of Medicinal Chemistry acs.jmedchem.7b01847
2018
Novel DYRK1A inhibitor rescues learning and memory deficits in a mouse model of down syndrome
Wenche Stensen , Ulli Rothweiler , Richard Alan Engh , Melissa R Stasko
Pharmaceuticals 14 ( 11) 1170 -1170
9
2021
Ultrafast dynamics of tryptophan: simulation and experiment
Richard Alan Engh
The University of Chicago
1987
Tryptophan Structure and Dynamics Using GROMOS
RICHARD A. ENGH , LIN X. CHEN , GRAHAM R. FLEMING
Annals of the New York Academy of Sciences 482 ( 1) 304 -306
1986
THE STRUCTURE OF CYSTATINS AND THEIR INTERACTIONS WITH COGNATE CYSTEINE PROTEINASES
W BODE , M STUBBS , D MUSIL , B LABER
JOURNAL OF CELLULAR BIOCHEMISTRY 123 -123
1994
The Three-Dimensional Structure of<* 1 AT
RICHARD A ENGH , WOLFRAM BODE
Alpha 1-Antitrypsin Deficiency: Biology-Pathogenesis-Clinical Manifestations-Therapy 77 -77
2014
PRODUCTION AND CHARACTERIZATION OF DELETION AND SUBSTITUTION MUTANTS OF CYSTATINS AS WELL AS OF CYSTATIN DIMERS
EA AUERSWALD , DK NAGLER , M BERND , W MACHLEIDT
JOURNAL OF CELLULAR BIOCHEMISTRY 150 -150
1994
Antitumoral and mechanistic studies of ianthelline isolated from the Arctic sponge Stryphnus fortis.
Trine Stiberg , Jeanette H. Andersen , Anne-Marie GENEVIèRE , Richard A. Engh
Anticancer Research 32 ( 10) 4287 -4297
15
2012
Dynamics simulation studies of apoazurin of Alcaligenes denitrificans
Lin X. Q. Chen , Richard A. Engh , Axel T. Bruenger , Dzung T. Nguyen
Biochemistry 27 ( 18) 6908 -6921
17
1988
The structure of a dual-specificity tyrosine phosphorylation-regulated kinase 1A-PKC412 complex reveals disulfide-bridge formation with the anomalous catalytic loop HRD(HCD) cysteine.
Marina Alexeeva , Espen Åberg , Richard A. Engh , Ulli Rothweiler
Acta Crystallographica Section D-biological Crystallography 71 ( 5) 1207 -1215
14
2015
X-ray Structure of Active Site-inhibited Clotting Factor Xa IMPLICATIONS FOR DRUG DESIGN AND SUBSTRATE RECOGNITION
Hans Brandstetter , Anja Kühne , Wolfram Bode , Robert Huber
Journal of Biological Chemistry 271 ( 47) 29988 -29992
234
1996
Structural aspects of serpin inhibition.
Andreas J. Schulze , Robert Huber , Wolfram Bode , Richard A. Engh
FEBS Letters 344 117 -124
56
1994
Structure of leech derived tryptase inhibitor (LDTI-C) in solution
Peter Mühlhahn , Michael Czisch , Robert Morenweiser , Bianca Habermann
FEBS Letters 355 ( 3) 290 -296
38
1994
Hans Brandstetter Karl-Peter Hopfner Nikolas von Bubnoff Graham Fleming Osman Gani John S. Mjøen Svendsen Christian Klein Milton T. Stubbs Andrey Karshikoff dusan turk Lin X. Chen Guy Georges Maria Joao Romao Martin Renatus Balmukund Thakkar Dr. Rama Krishna Kancha P D J Grootenhuis Johan Isaksson Stefan Bonn Manfred Schwaiger