Richard A. Engh
机构: Professor of Chemistry, UiT the Arctic University of Norway
每年引用次数
引用次数
引用: 13,111
H-指数: 50
I10-指数 : 101
出版物: 188
DERIVATIVES OF 4-AMINO-PYRIDINE AS SELECTIVE THROMBIN INHIBITORS
Wolfgang von der Saal , Ralf Kucznierz , Herbert Leinert , Richard A. Engh
Bioorganic & Medicinal Chemistry Letters 7 ( 10) 1283 -1288
34
1997
Structural aspects of protein kinase control—role of conformational flexibility
Richard A. Engh , Dirk Bossemeyer
Pharmacology & Therapeutics 93 ( 2-3) 99 -111
77
2002
VX680 binding in Aurora A: π-π interactions involving the conserved aromatic amino acid of the flexible glycine-rich loop.
Taianá M. Oliveira , Rafi Ahmad , Richard A. Engh
Journal of Physical Chemistry A 115 ( 16) 3895 -3904
10
2011
p38α MAP kinase dimers with swapped activation segments and a novel catalytic loop conformation.
Ulli Rothweiler , Espen Åberg , Kenneth A. Johnson , Tom E. Hansen
Journal of Molecular Biology 411 ( 2) 474 -485
13
2011
156 Lysine 156 promotes the anomalous proenzyme activity of tPA: X-ray crystal structure of single chain human tPA and vampire bat plasminogen activator
Martin Renatus , Richard A. Engh , Milton T. Stubbs , Robert Huber
Fibrinolysis and Proteolysis 11 44
1997
Divining the serpin inhibition mechanism: a suicide substrate ‘springe’?
Richard A. Engh , Robert Huber , Wolfram Bode , Andreas J. Schulze
Trends in Biotechnology 13 ( 12) 503 -510
70
1995
Luciferin and derivatives as a DYRK selective scaffold for the design of protein kinase inhibitors.
Ulli Rothweiler , Jonas Eriksson , Wenche Stensen , Frederick Leeson
European Journal of Medicinal Chemistry 94 140 -148
17
2015
Phthalazinone pyrazoles as potent, selective, and orally bioavailable inhibitors of Aurora-A kinase.
Michael E. Prime , Stephen M. Courtney , Frederick A. Brookfield , Richard W. Marston
Journal of Medicinal Chemistry 54 ( 1) 312 -319
57
2011
Evidence for the extent of insertion of the active site loop of intact alpha 1 proteinase inhibitor in beta-sheet A.
Andreas J. Schulze , Paul W. Frohnert , Richard A. Engh , Robert Huber
Biochemistry 31 ( 33) 7560 -7565
76
1992
Removal of Coherent Coupling Artifact in Ground-State Recovery Experiments: Malachite Green in Water-Methanol Mixtures
Richard A. Engh , Jacob W. Petrich , Graham R. Fleming
The Journal of Physical Chemistry 89 ( 4) 618 -621
38
1985
Multiple Conformations of Cystatin, Mung Bean Inhibitor, and Serpins
Richard A. Engh , Robert Huber , Wolfram Bode
NATO ASI Series 351 -368
1994
FMS-like tyrosine kinase 3-internal tandem duplication tyrosine kinase inhibitors display a nonoverlapping profile of resistance mutations in vitro.
Nikolas von Bubnoff , Richard A. Engh , Espen Åberg , Jana Sänger
Cancer Research 69 ( 7) 3032 -3041
86
2009
Mutants of protein kinase A that mimic the ATP-binding site of Aurora kinase
Alexander Pflug , Taianá Maia de Oliveira , Dirk Bossemeyer , Richard A. Engh
Biochemical Journal 440 ( 1) 85 -93
9
2011
Conformational dynamics of tryptophan: a proposal for the origin of the non-exponential fluorescence decay
Richard A. Engh , Lin X.-Q. Chen , Graham R. Fleming
Chemical Physics Letters 126 ( 3-4) 365 -372
67
1986
Comparative conformational analyses and molecular dynamics studies of glycylglycine methyl ester and glycylglycine N-methylamide
Balmukund S. Thakkar , Richard A. Engh
RSC Advances 8 ( 8) 4445 -4453
1
2018
NMR Structures of Serine Proteinase Inhibitors LDTI and RBI, and Comparison With X-ray Structures
Tad A. Holak , Richard A. Engh
Dynamics and the Problem of Recognition in Biological Macromolecules 9 -27
1996
Differential Sensitivity of ERBB2 Kinase Domain Mutations towards Lapatinib
Rama Krishna Kancha , Nikolas von Bubnoff , Natalie Bartosch , Christian Peschel
PLoS ONE 6 ( 10) e26760
89
2011
Reorientation of tryptophan and simple peptides: onset of internal flexibility and comparison with molecular dynamics simulation
Lin X. Q. Chen , Richard A. Engh , Graham R. Fleming
The Journal of Physical Chemistry 92 ( 16) 4811 -4816
19
1988
The Protein Kinase C Inhibitor Bisindolyl Maleimide 2 Binds with Reversed Orientations to Different Conformations of Protein Kinase A
Michael Gassel , Christine B. Breitenlechner , Norbert König , Robert Huber
Journal of Biological Chemistry 279 ( 22) 23679 -23690
33
2004
Anomalous dispersion analysis of inhibitor flexibility: a case study of the kinase inhibitor H-89
Alexander Pflug , Kenneth A. Johnson , Richard A. Engh
Acta Crystallographica Section F-structural Biology and Crystallization Communications 68 ( 8) 873 -877
9
2012
Hans Brandstetter Karl-Peter Hopfner Nikolas von Bubnoff Graham Fleming Osman Gani John S. Mjøen Svendsen Christian Klein Milton T. Stubbs Andrey Karshikoff dusan turk Lin X. Chen Guy Georges Maria Joao Romao Martin Renatus Balmukund Thakkar Dr. Rama Krishna Kancha P D J Grootenhuis Johan Isaksson Stefan Bonn Manfred Schwaiger