Reduction in Ultrasonic Vocalizations in Pups Born to Rapid Eye Movement Sleep Restricted Mothers in Rat Model

摘要: The effects of rapid eye movement sleep restriction (REMSR) in rats during late pregnancy were studied on the ultrasonic vocalizations (USVs) made by pups. USVs are distress calls inaudible to human ears. Rapid (REM) was restricted one group pregnant for 22 hours, starting from gestational day 14 20, using standard single platform method. male pups recorded after a brief isolation their mother two minutes alternate post-natal days, till weaning. microphones and analysed qualitatively quantitatively SASPro software. Control produced maximum vocalization days 9 11. In comparison, born REMSR mothers showed not only reduction but also delay peak call making days. experimental variations types characteristics types, alteration temporal profile. blunting response these indicates that maternal plays role regulating neural development involved possibly shaping emotional behaviour neonates. It is suggested reduced can be utilized as reliable early marker affective state rat Such impaired responses could provide an important lead understanding mother-child bonding optimal cognitive post-partum life. This first report showing potential link between REM deprivation neonates infants.