Therapy-related Myeloid Neoplasms After Autologous Hematopoietic Stem Cell Transplantation in Lymphoma Patients

摘要: Lymphoma patients treated with autologous transplantation (ASCT) live an increasingly long life the recent advancement in therapeutic modalities. This has resulted increase incidence of therapy-related myeloid neoplasms (t-MN), which is one leading causes non-relapse mortality. Several observational studies have linked development t-MN after ASCT intensity and frequency chemotherapy, particularly alkylating agents, use total body irradiation (TBI), peripheral blood progenitor cells. In addition, role genetic factors being identified. It postulated that chemotherapy prior to results DNA damage cells, mitochondrial dysfunction, altered gene expression related repair, metabolism as well hematopoietic regulation. Cytogenetic shown presence abnormalities cells ASCT. is, therefore, likely reinfusion proliferative stress on infused during regeneration associated telomere shortening ultimately result clonal hematopoiesis blastic transformation. Cytopenias, myelodysplasia, or cytogenetic are common can be transient ASCT; only when present together, they do confirm diagnosis t-MN. Attempts reduce occurrence should directed toward minimizing exposure identified risk factors. Although median survival few months less than a year, promising allogeneic select young without high-risk cytogenetics. this review we will explain findings field lymphoma implications for identifying molecular mechanisms leukemogenesis discuss potential strategies patient population.