Impact of linoleic acid supplementation on lovastatin production in Aspergillus terreus cultures
作者： Flavia Sorrentino , Ipsita Roy , Tajalli Keshavarz
DOI: 10.1007/S00253-010-2722-0
关键词: Transcriptional regulation 、 Linoleic acid 、 Biochemistry 、 Secondary metabolite 、 Aspergillus terreus 、 Oxylipin 、 Fungi imperfecti 、 Biology 、 Lovastatin 、 Gene 、 Biotechnology 、 Applied Microbiology and Biotechnology 、 General Medicine
摘要: This work proposes a novel approach for enhancing the yield of lovastatin in Aspergillus terreus cultures by exploiting linoleic acid-derived signalling molecules, which are potentially involved fungal cell-cell communication. High-performance liquid chromatography analysis revealed that production was enhanced up to 1.8-fold upon exogenous addition oxylipin precursor acid low cell density A. terreus. Real-time PCR showed supplementation also resulted an increase transcriptional levels biosynthetic genes lovB and lovF, indicating control fatty acids (linoleic acid) on these study therefore demonstrates first time potential molecule as enhancer secondary metabolite with positive impact industrial exploitation.
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