Proto-oncogene PML controls genes devoted to MHC class I antigen presentation

作者: Pan Zheng , Yong Guo , Qingtian Niu , David E. Levy , Jacqueline A. Dyck

DOI: 10.1038/24628

关键词: Transporter associated with antigen processingMHC class IMajor histocompatibility complexAntigen presentationMHC restrictionCD74Antigen processingMHC class I antigenCell biologyBiologyImmunology

摘要: … Here we report that the proto-oncogene product PML induces expression of LMP-2, LMP-7, TAP-1 and TAP-2 in an MHC-class I-negative, recurrent tumour, leading to the re-expression …

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