Chemical reactivity drives spatiotemporal organisation of bacterial metabolism

摘要: In this review, we examine how bacterial metabolism is shaped by chemical constraints acting on the material and dynamic layout of enzymatic networks beyond. These are moulded not only for optimisation given metabolic objectives (e.g. synthesis a particular amino acid or nucleotide) but also curbing detrimental reactivity intermediates. Besides substrate channelling, toxicity avoided barriers to free diffusion (i.e. compartments) that separate otherwise incompatible reactions, along with ways distinguishing damaging vs. harmless molecules. On other hand, enzymes age their operating lifetime must be tuned upstream downstream reactions. This time dependence pathways creates time-linked information, learning memory. features suggest physical structure existing biosystems, from operon assemblies multicellular development may ultimately stem need restrain damage limit waste inherent basic functions. provides new twist our comprehension fundamental biological processes in live systems as well practical take-home lessons forward DNA-based engineering novel objects.