Molecular biology and replication of hepatitis E virus

摘要: Hepatitis E virus (HEV), a single-stranded, positive-sense RNA virus, is responsible for acute hepatitis epidemics in many developing countries, and the also endemic some industrialized countries. recognized zoonotic disease, several animal species, including pigs, are potential reservoirs HEV. The genome of HEV contains three open reading frames (ORFs). ORF1 encodes nonstructural proteins, ORF2 capsid protein, ORF3 small multifunctional protein. proteins translated from single, bicistronic mRNA. coding sequences these two ORFs overlap each other, but neither overlaps with ORF1. Whereas mechanisms underlying replication poorly understood, construction infectious viral clones, identification cell lines that support replication, development models have allowed more detailed study virus. As result advances, recently, our understanding entry, genomic egress has improved. Furthermore, determination T=1 T=3 structure virus-like particles furthered This article reviews latest developments molecular biology an emphasis on organization, expression function genes,