Nitric oxide inhibition and consecutive Aspisol application show a prolonged survival of orthotopic transplanted livers in a rat model.

摘要: Background. It is generally accepted that nitric oxide (NO) plays a crucial role in acute rejection caused by inflammatory responses. Therefore, the purpose of this study was to investigate effect on survival following arterialized orthotopic rat liver transplantations (o-RLTx) NO inhibition and consequent blockade platelet aggregation application Aspisol. Materials Methods. Inbred LEWIS-(RT 1 ) rats underwent o-RLTx under ether anesthesia with DA-(RTlavl) as organ donors. After transplantation, serum parameters were determined hepatic biopsy specimens sampled postoperative days 5, 8, 10, 30, 90. Sixty-one divided into 5 groups: syngenic controls (group I, n = 12); allogenic II, 11); FK506 immunosuppression III, AGH-treatment IV, 13); AGH/low- dose Aspisol treatment for after transplantation V, 13) (Bayer, Leverkusen, Germany). Results. Rats group V AGH/low-dose showed significantly longer graft (18.2 +/- 1.8 days) compared II untreated grafts (11.3 1.7 IV AGH (11.2 +/-1.8 days; P <.05). Histological examination revealed moderate among AGH-treated IV; however, marked sinusoids present, which not observed Aspisol-treated animals V). Conclusion. Our data suggested simultaneous leads significant increase transplantation.