The effects of aldose reductase inhibition with ponalrestat on changes in vascular function in streptozotocin diabetic rats
作者： Donna J. Otter , Russell Chess-Williams
DOI: 10.1111/J.1476-5381.1994.TB17028.X
关键词: Sodium nitroprusside 、 Polyol pathway 、 Aldose reductase inhibitor 、 Carbachol 、 Phenylephrine 、 Chemistry 、 Aldose reductase 、 Forskolin 、 Streptozotocin 、 Internal medicine 、 Endocrinology
摘要: 1. The responses of rat isolated aortae to vasoconstrictor and vasodilator agents have been studied in 14-day streptozotocin-diabetic rats. effects treatment with the aldose reductase inhibitor, ponalrestat, on these also investigated. 2. Maximum contractile aortic sensitivity phenylephrine were significantly enhanced diabetic aortae. 3. In contrast, endothelium-dependent relaxations carbachol depressed rats, whilst endothelium-independent forskolin sodium nitroprusside unchanged. 4. Pretreatment ponalrestat (25 mg kg-1, daily) prevented both maximum from Ponalrestat however, had no effect reduced EC50 values observed tissues animals. 5. It is concluded that prevents depression induced by diabetes 14 days duration, suggesting polyol pathway involved vascular changes. does not prevent increase alpha 1-adrenoceptor agonists.
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