Effect of glucagon-like peptide-1(7-36) and exendin-4 on the vascular reactivity in streptozotocin/nicotinamide-induced diabetic rats.
作者： Sibel Özyazgan , Nilüfer Kutluata , Selim Afşar , Şule Beyhan Özdaş , Ahmet Gökhan Akkan
DOI: 10.1159/000084277
关键词:
摘要: We investigated the vascular effects of glucagon-like peptide-1 (GLP-1) and Exendin-4 in type 2 diabetic rat aortae. Studies were performed a normal control group (NC) (0.2 ml i.p. saline, n = 10), streptozotocin (STZ)/nicotinamide (DC) (a single dose 80 mg/kg STZ injection 15 min after administration 230 nicotinamide i.p.), GLP-1 (GLPC) (1 µg/kg twice daily for 1 month, (EXC) (0.1 GLP-1-treated (GLPT) Exendin-4-treated (EXT) 10). One month treatment significantly decreased blood glucose levels rats (113 ± mg/dl, p 2) maximum response (% Max. Relax) acetylcholine-stimulated relaxations DC (pD2: 6.73 0.12 55 6, respectively) compared with non-diabetic NC 7.41 0.25, values Exendin-4, Relax %values aortic strips to acetylcholine returned near 7.47 0.15, max) noradrenaline from (341 27 mg tension/mg wet weight) (540 66 weight, all groups. Emax KCl (247 10 max (271 12 weight). (partially) could improve increased level normalize altered tone rats.
karger.com
sci-hub.se 参考文章(66)
N D Evcimen, S Nebioglu, Calmodulin glycation in diabetic rat lenses. Canadian Journal of Physiology and Pharmacology. ,vol. 74, pp. 1287- 1293 ,(1996) , 10.1139/Y96-092
Galen M. Pieper, Bruce A. Peltier, Amelioration by L-arginine of a dysfunctional arginine/nitric oxide pathway in diabetic endothelium. Journal of Cardiovascular Pharmacology. ,vol. 25, pp. 397- 403 ,(1995) , 10.1097/00005344-199503000-00008
Mark Gutniak, Cathrine Ørkov, Jens J Holst, Bo Ahrén, Suad Efendić, None, Antidiabetogenic effect of glucagon-like peptide-1 (7-36)amide in normal subjects and patients with diabetes mellitus. The New England Journal of Medicine. ,vol. 326, pp. 1316- 1322 ,(1992) , 10.1056/NEJM199205143262003
S. Ramanadham, W. H. Lyness, T. E. Tenner Jr., Alterations in aortic and tail artery reactivity to agonists after streptozotocin treatment Canadian Journal of Physiology and Pharmacology. ,vol. 62, pp. 418- 423 ,(1984) , 10.1139/Y84-066
Thomas Nyström, Adrian T. Gonon, Åke Sjöholm, John Pernow, Glucagon-like peptide-1 relaxes rat conduit arteries via an endothelium-independent mechanism. Regulatory Peptides. ,vol. 125, pp. 173- 177 ,(2005) , 10.1016/J.REGPEP.2004.08.024
R. Testa, L. Guarneri, E. Poggesi, I. Simonazzi, C. Taddei, A. Leonardi, Mediation of noradrenaline‐induced contractions of rat aorta by the (α1B‐adrenoceptor subtype British Journal of Pharmacology. ,vol. 114, pp. 745- 750 ,(1995) , 10.1111/J.1476-5381.1995.TB13267.X
E. M. Egido, R. A. Silvestre, R. Hernández, J. Marco, Exendin-4 dose-dependently stimulates somatostatin and insulin secretion in perfused rat pancreas. Hormone and Metabolic Research. ,vol. 36, pp. 595- 600 ,(2004) , 10.1055/S-2004-825921
S Bonner-Weir, D F Trent, G C Weir, Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release. Journal of Clinical Investigation. ,vol. 71, pp. 1544- 1553 ,(1983) , 10.1172/JCI110910
Donna J. Otter, Russell Chess-Williams, The effects of aldose reductase inhibition with ponalrestat on changes in vascular function in streptozotocin diabetic rats British Journal of Pharmacology. ,vol. 113, pp. 576- 580 ,(1994) , 10.1111/J.1476-5381.1994.TB17028.X
I. Cohen, D. Burk, R.J. Fullerton, A. Veis, D. Green, Nonenzymatic glycation of human blood platelet proteins Thrombosis Research. ,vol. 55, pp. 341- 349 ,(1989) , 10.1016/0049-3848(89)90066-2