Alterations in aortic and tail artery reactivity to agonists after streptozotocin treatment

摘要: In the present study, responses to various agonists in thoracic aorta and tail artery strips, obtained from 4-week streptozotocin (STZ)-treated rats age-matched controls, were studied. Responses diabetic animals alpha-agonists, norepinephrine (NE), methoxamine (MOX), calcium (Ca2+) potassium (K+) found be depressed relative control tissue. however, different. While K+ decreased Ca2+ unchanged, strips supersensitive both alpha-agonists Another observed difference between two tissues was their catecholamine content. induction of diabetes did not alter levels aorta, a significant decrease produced artery, tissue levels. Our results indicate that inherent differences (such as degree innervation) may contribute differential They further suggest possible involvement alterations utilization development postjunctional supersensitivity STZ-treated animals.