Augmented inositol phosphate production in mesenteric arteries from diabetic rats.
作者： Worku Abebe , Kathleen M. MacLeod
DOI: 10.1016/0922-4106(92)90035-T
关键词: Second messenger system 、 Mesenteric arteries 、 Inositol phosphate 、 Diabetes mellitus 、 Inositol 、 Contraction (grammar) 、 Prazosin 、 Vasoconstriction 、 Endocrinology 、 Biology 、 Internal medicine
摘要: Abstract The effects of noradrenaline (NA) on contraction and phosphoinositide metabolism were compared in mesenteric arteries from rats with chronic streptozotocin-induced diabetes age-matched control rats. Maximum contractile responses diabetic to NA (30 μM) significantly greater than both the presence absence extracellular Ca2+. Basal incorporation [3H]myoinositol into total [3H]inositol phosphates was arteries. resulted a time-dependent increase phosphate production, which also preparations. produced by arterie blocked α1-adrenoceptor antagonists, prazosin. Absolute levels inositol 1,4,5-trisphosphate (I(1,4,5)P3), measured protein binding assay, increased response 30 μM Although basal I(1,4,5)P3 not different, NA-induced increases at each time-point measured. These data indicate that is enhanced maximum concentration NA. Augmented production second messengers presumably, 1,2-diacylgylcerol may contribute
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