Mass changes of inositol(1,4,5)trisphosphate in trachealis muscle following agonist stimulation.
作者： Edwin R. Chilvers , R.A. John Challiss , Peter J. Barnes , Stafan R. Nahorski
DOI: 10.1016/0014-2999(89)90269-0
关键词: Inositol phosphate 、 Cortex (botany) 、 Stimulation 、 Trachealis muscle 、 Inositol 、 Carbachol 、 Biology 、 Endocrinology 、 Internal medicine 、 Agonist 、 Basal (phylogenetics)
摘要: Abstract Agonist-stimulated changes in D-Ins(1,4,5)P 3 has been examined tracheal smooth muscle using a specific radioreceptor assay utilizing the binding of [ H] or 32 P]Ins(1,4,5)P to bovine adrenal cortex preparation. Carbachol produced maximal increase Ins(1,4,5)P concentration after 5 s (basal: 12.9 ± 0.8; stimulated: 27 1.5 pmol/mg protein) with an EC 50 6.7 0.8 μ M. With longer stimulation periods rapidly returned basal values by 30 s. This is first report mass measurements muscle.
elsevier.com
sci-hub.se 参考文章(11)
T J Biden, C B Wollheim, Ca2+ regulates the inositol tris/tetrakisphosphate pathway in intact and broken preparations of insulin-secreting RINm5F cells. Journal of Biological Chemistry. ,vol. 261, pp. 11931- 11934 ,(1986) , 10.1016/S0021-9258(18)67180-7
W C Miller-Hance, J R Miller, J N Wells, J T Stull, K E Kamm, Biochemical events associated with activation of smooth muscle contraction. Journal of Biological Chemistry. ,vol. 263, pp. 13979- 13982 ,(1988) , 10.1016/S0021-9258(18)68171-2
Inositol trisphosphate, calcium and muscle contraction. Philosophical Transactions of the Royal Society B. ,vol. 320, pp. 399- 414 ,(1988) , 10.1098/RSTB.1988.0084
L M Molina y Vedia, E G Lapetina, Phorbol 12,13-dibutyrate and 1-oleyl-2-acetyldiacylglycerol stimulate inositol trisphosphate dephosphorylation in human platelets. Journal of Biological Chemistry. ,vol. 261, pp. 10493- 10495 ,(1986) , 10.1016/S0021-9258(18)67411-3
Toshihiko Hashimoto, Masato Hirata, Yushi Ito, A role for inositol 1,4,5‐trisphosphate in the initiation of agonist‐induced contractions of dog tracheal smooth muscle British Journal of Pharmacology. ,vol. 86, pp. 191- 199 ,(1985) , 10.1111/J.1476-5381.1985.TB09449.X
Guy P. Heathers, Peter B. Corr, Leona J. Rubin, Transient accumulation of inositol (1,3,4,5)-tetrakisphosphate in response to α1-adrenergic stimulation in adult cardiac myocytes Biochemical and Biophysical Research Communications. ,vol. 156, pp. 485- 492 ,(1988) , 10.1016/S0006-291X(88)80867-2
I.P. Hall, S.J. Hill, β ‐Adrenoceptor stimulation inhibits histamine‐stimulated inositol phospholipid hydrolysis in bovine tracheal smooth muscle British Journal of Pharmacology. ,vol. 95, pp. 1204- 1212 ,(1988) , 10.1111/J.1476-5381.1988.TB11757.X
Susan Palmer, Kelvin T. Hughes, Denise Y. Lee, Michael J.O. Wakelam, Development of a novel, Ins(1,4,5)P3-specific binding assay. Its use to determine the intracellular concentration of Ins(1,4,5)P3 in unstimulated and vasopressin-stimulated rat hepatocytes. Cellular Signalling. ,vol. 1, pp. 147- 156 ,(1989) , 10.1016/0898-6568(89)90004-1
R.A. John Challiss, Ian H. Batty, Stefan R. Nahorski, Mass measurements of inositol(1,4,5)trisphosphate in rat cerebral cortex slices using a radioreceptor assay: Effects of neurotransmitters and depolarization Biochemical and Biophysical Research Communications. ,vol. 157, pp. 684- 691 ,(1988) , 10.1016/S0006-291X(88)80304-8
Ad F. Roffel, Jan Bert Postema, Adiet Timmermans, Carolina R.S. Elzinga, Henk F. Kauffman, Johan Zaagsma, Herman Meurs, EVIDENCE FOR A DIRECT RELATIONSHIP BETWEEN PHOSPHOINOSITIDE METABOLISM AND AIRWAY SMOOTH-MUSCLE CONTRACTION INDUCED BY MUSCARINIC AGONISTS European Journal of Pharmacology. ,vol. 156, pp. 271- 274 ,(1988) , 10.1016/0014-2999(88)90331-7