Low Serum Concentrations of 1,25-Dihydroxyvitamin D in Human Magnesium Deficiency
作者： ROBERT K. RUDE , JOHN S. ADAMS , ELISABETH RYZEN , DAVID B. ENDRES , HIROO NIIMI
关键词: Basal (phylogenetics) 、 Calcium 、 Vitamin D and neurology 、 Internal medicine 、 Endocrinology 、 Steroid hormone 、 Magnesium deficiency (medicine) 、 Magnesium 、 Hypomagnesemia 、 Chemistry 、 Hormone
摘要: The effect of magnesium deficiency on vitamin D metabolism was assessed in 23 hypocalcemic magnesium-deficient patients by measuring the serum concentrations 25-hydroxyvitamin (25OHD) and 1,25-dihydroxyvitamin [1,25-(OH2D] before, during, after 5-13 days parenteral therapy. Magnesium therapy raised mean basal [1.0 ± 0.1 (mean SEM) mg/dl] calcium levels (7.2 0.2 mg/dl) into normal range (2.2 9.3 mg/dl, respectively; P < 0.001). 25OHD concentration low (13.2 1.5 ng/ml) before administration did not significantly change this (14.8 ng/ml). Sixteen had 1,25-(OH)2D (<30 pg/ml). After therapy, only 5 a rise or above despite elevated immunoreactive PTH. An additional normocalcemic hypomagnesemic patient (had 1,25-(OH)2D)levels w...
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