Characterization of a MEN1 ortholog from Drosophila melanogaster

摘要: Abstract Multiple endocrine neoplasia type 1 (MEN1) is a familial cancer syndrome characterized by tumors of the parathyroid, entero-pancreatic neuroendocrine and pituitary tissues caused inactivating mutations in MEN1 gene. Menin, 610-amino acid nuclear protein encoded , binds to transcription factor JunD can repress JunD-induced transcription. We report here identification ortholog Drosophila melanogaster Menin1 that encodes 763 amino sharing 46% identity with human menin. Additionally, 69% missense in-frame deletions reported patients appear residues are identical protein, suggesting importance conserved regions. gene transcripts use alternative polyadenylation sites resulting 4.3 5-kb messages. The 4.3-kb transcript appears be largely maternal, while mainly zygotic. binding menin or Jun could not demonstrated yeast two-hybrid analysis. from will provide an opportunity utilize genetics enhance our understanding function