The role of the vasopressin V1A receptor in oxytocin modulation of methamphetamine primed reinstatement

摘要: Abstract The neuropeptide oxytocin has shown promise as an effective therapy in pre-clinical models of methamphetamine (METH) addiction. nucleus accumbens core (NAcc) been identified important site for to inhibit METH behaviours, although previous findings suggest that the effects NAcc are mediated by receptors other than receptor (OTR). Oxytocin high affinity vasopressin V1A (V1AR) which implicated numerous oxytocin-dependent social behaviours. aim this study was investigate involvement V1AR mediating effect treatment reduce METH-primed reinstatement METH-seeking behaviour. Male rats were trained self-administer intravenous infusions lever press during daily 2-h fixed ratio 1 scheduled sessions 20 days. Following extinction pressing, tested alone, co-administered with a selective antagonist, or OTR on reinstatement, when administered systemically, microinjected into NAcc. Systemic administration prevented significantly reduced systemic pre-treatment but not antagonist. Local blocked. Our results demonstrate substantial role inhibitory and indicate need investigations differential V1ARs OTRs oxytocin-induced reduction METH-related