Use of protein tyrosine phosphatase inhibitors as promising targeted therapeutic drugs.

作者： P. Heneberg

DOI: 10.2174/092986709787458407

关键词: Enzyme 、 Natural product 、 Gene silencing 、 In vivo 、 Pharmacology 、 Biochemistry 、 Enzyme inhibitor 、 Suramin 、 Protein tyrosine phosphatase 、 Biological activity 、 Chemistry

摘要: … are difficult to develop, lifting the fog of phosphatase inhibition is of the great market … -spectrum PTP inhibitor, sodium orthovanadate, was the only readily available PTP inhibitor used. …

参考文章(216)

Eva Wieckowski, Yoshinari Atarashi, Joanna Stanson, Taka-Aki Sato, Theresa L. Whiteside, FAP‐1‐mediated activation of NF‐κB induces resistance of head and neck cancer to fas‐induced apoptosis Journal of Cellular Biochemistry. ,vol. 100, pp. 16- 28 ,(2007) , 10.1002/JCB.20922

Jeffrey D. Bjorge, Andrew Pang, Donald J. Fujita, Identification of protein-tyrosine phosphatase 1B as the major tyrosine phosphatase activity capable of dephosphorylating and activating c-Src in several human breast cancer cell lines. Journal of Biological Chemistry. ,vol. 275, pp. 41439- 41446 ,(2000) , 10.1074/JBC.M004852200

Kunliang Guan, Jack E Dixon, None, Protein tyrosine phosphatase activity of an essential virulence determinant in Yersinia Science. ,vol. 249, pp. 553- 556 ,(1990) , 10.1126/SCIENCE.2166336

Jill L. Blanchard, David M. Epstein, Michael D. Boisclair, Johannes Rudolph, Kollol Pal, Dysidiolide and related γ-hydroxy butenolide compounds as inhibitors of the protein tyrosine phosphatase, CDC25 Bioorganic & Medicinal Chemistry Letters. ,vol. 9, pp. 2537- 2538 ,(1999) , 10.1016/S0960-894X(99)00431-X

Gang Liu, Zhili Xin, Zhonghua Pei, Philip J. Hajduk, Cele Abad-Zapatero, Charles W. Hutchins, Hongyu Zhao, Thomas H. Lubben, Stephen J. Ballaron, Deanna L. Haasch, Wiweka Kaszubska, Cristina M. Rondinone, James M. Trevillyan, Michael R. Jirousek, Fragment screening and assembly: a highly efficient approach to a selective and cell active protein tyrosine phosphatase 1B inhibitor. Journal of Medicinal Chemistry. ,vol. 46, pp. 4232- 4235 ,(2003) , 10.1021/JM034122O

Caitlin E. Hubbard, Amy M. Barrios, A Highly Efficient Route to Enantiomerically Pure l-N-Bz-Pmp(t-Bu)2-OH and Incorporation into a Peptide-Based Protein Tyrosine Phosphatase Inhibitor Bioorganic & Medicinal Chemistry Letters. ,vol. 18, pp. 679- 681 ,(2008) , 10.1016/J.BMCL.2007.11.056

Sylvia Streit, Jens Ernst Ruhe, Pjotr Knyazev, Tatjana Knyazeva, Stefano Iacobelli, Stephan Peter, Heinz Hoefler, Axel Ullrich, PTP-PEST phosphatase variations in human cancer. Cancer Genetics and Cytogenetics. ,vol. 170, pp. 48- 53 ,(2006) , 10.1016/J.CANCERGENCYTO.2006.05.013

Masato Takahashi, Kosuke Dodo, Yoshikazu Sugimoto, Yoshimi Aoyagi, Yuji Yamada, Yuichi Hashimoto, Ryuichi Shirai, Synthesis of the novel analogues of dysidiolide and their structure-activity relationship. Bioorganic & Medicinal Chemistry Letters. ,vol. 10, pp. 2571- 2574 ,(2000) , 10.1016/S0960-894X(00)00527-8

Akihiro Fujikawa, Daisuke Shirasaka, Shoichi Yamamoto, Hiroyoshi Ota, Kinnosuke Yahiro, Masahide Fukada, Takafumi Shintani, Akihiro Wada, Nobuo Aoyama, Toshiya Hirayama, Hiroshi Fukamachi, Masaharu Noda, Mice deficient in protein tyrosine phosphatase receptor type Z are resistant to gastric ulcer induction by VacA of Helicobacter pylori Nature Genetics. ,vol. 33, pp. 375- 381 ,(2003) , 10.1038/NG1112

Wei Zhang, Di Hong, Yueyang Zhou, Yinan Zhang, Qiang Shen, Jing-ya Li, Li-hong Hu, Jia Li, Ursolic acid and its derivative inhibit protein tyrosine phosphatase 1B, enhancing insulin receptor phosphorylation and stimulating glucose uptake Biochimica et Biophysica Acta. ,vol. 1760, pp. 1505- 1512 ,(2006) , 10.1016/J.BBAGEN.2006.05.009