Downregulation of ZMYND11 induced by miR-196a-5p promotes the progression and growth of GBM

摘要: ZMYND11 (zinc finger MYND-type containing 11) has been widely regarded to be involved in a variety of cancers as potential suppressor. However, the biological role and mechanism glioblastoma multiform (GBM) remain unknown. In this study, we found that expression was remarkably decreased GBM tissues from 20 cases cell line (U87) compared normal brain tissue 10 (P < 0.001). Furthermore, explored upregulation significantly suppressed U87 cells proliferation invasion, induced cycle arrest apoptosis in vitro. Subsequently, identified increased inhibited tumor growth using cells xenograft experiment on rude mice. Moreover, new direct functional target miR-196a-5p U87 via luciferase reporter assay. addition, confirmed negative correlation between by changing level with lentivirus plasmid vector. demonstrated could reverse suppressive effect downregulated rescue experiment. Taken together, extremely promising suppressor GBM, while miRNA-196a-5p quite an important treatment GBM.