Visual evaluation and differentiation of renal oncocytomas from renal cell carcinomas by means of 99m Tc-sestamibi SPECT/CT

作者: Antonios Tzortzakakis , Ove Gustafsson , Mattias Karlsson , Linnea Ekström-Ehn , Rammin Ghaffarpour

DOI: 10.1186/S13550-017-0278-Z

关键词: MedicineBiopsyCancerNuclear medicineChromophobe cellCardiac imagingRadiologyRenal biopsyRenal neoplasmPapillary renal cell carcinomasOncocytoma

摘要: Despite the progress in quality of multiphasic CT and MRI scans, it is still difficult to fully characterize a solid kidney lesion. Approximately 10% all renal tumours turn out be oncocytomas. In actual clinical practice, this verified only following unnecessary surgery or biopsy/ablation. The objective our pilot study examines whether 99mTc-sestamibi SPECT/CT can play crucial role characterization neoplasms differentiation oncocytomas from cell carcinomas. included 27 patients identified with 31 lesions. All were discussed multidisciplinary conference, decision for biopsy was taken. Prior invasive procedures, underwent 99mTc-sestamibi. Visual evaluation performed, any focal uptake detected on SPECT localisation tumour considered as positive. Eleven 12 (91.6%) displayed positive Three hybrid (mixed-type oncocytoma chromophobe cancer) SPECT/CT. One papillary carcinoma had slight remaining 11 carcinomas sestamibi negative. Differentiation benign seems very promising examination. Additional supplement visual evaluation, i.e. quantitative tools, should sought an accurate estimate biological behaviour hence secure diagnosis.

参考文章(30)
Michael J. Lipsky, Christopher M. Deibert, James M. McKiernan, Epidemiology, Screening, and Clinical Staging Springer New York. pp. 1- 18 ,(2013) , 10.1007/978-1-4614-7236-0_1
Stella K. Kang, Angela Zhang, Pari V. Pandharipande, Hersh Chandarana, R. Scott Braithwaite, Benjamin Littenberg, DWI for Renal Mass Characterization: Systematic Review and Meta-Analysis of Diagnostic Test Performance American Journal of Roentgenology. ,vol. 205, pp. 317- 324 ,(2015) , 10.2214/AJR.14.13930
Michael A. Gorin, Steven P. Rowe, Alexander S. Baras, Lilja B. Solnes, Mark W. Ball, Phillip M. Pierorazio, Christian P. Pavlovich, Jonathan I. Epstein, Mehrbod S. Javadi, Mohamad E. Allaf, Prospective Evaluation of 99mTc-sestamibi SPECT/CT for the Diagnosis of Renal Oncocytomas and Hybrid Oncocytic/Chromophobe Tumors European Urology. ,vol. 69, pp. 413- 416 ,(2016) , 10.1016/J.EURURO.2015.08.056
Yasuhisa Fujii, Yoshinobu Komai, Kazutaka Saito, Yasumasa Iimura, Junji Yonese, Satoru Kawakami, Yuichi Ishikawa, Jiro Kumagai, Kazunori Kihara, Iwao Fukui, Incidence of benign pathologic lesions at partial nephrectomy for presumed RCC renal masses: Japanese dual-center experience with 176 consecutive patients. Urology. ,vol. 72, pp. 598- 602 ,(2008) , 10.1016/J.UROLOGY.2008.04.054
GEORGE LARCOS, BRIAN P. MULLAN, LEE A. FORSTROM, Scintigraphic findings of renal oncocytoma Clinical Nuclear Medicine. ,vol. 18, pp. 884- 886 ,(1993) , 10.1097/00003072-199310000-00012
Astrid Fittschen, Inka Wendlik, Suemeyra Oeztuerk, Wolfgang Kratzer, Atilla S. Akinli, Mark M. Haenle, Tilmann Graeter, Prevalence of sporadic renal angiomyolipoma: a retrospective analysis of 61,389 in- and out-patients Abdominal Imaging. ,vol. 39, pp. 1009- 1013 ,(2014) , 10.1007/S00261-014-0129-6
CHRISTOPHER B. DECHET, DAVID G. BOSTWICK, MICHAEL L. BLUTE, SANDRA C. BRYANT, HORST ZINCKE, RENAL ONCOCYTOMA: MULTIFOCALITY, BILATERALISM, METACHRONOUS TUMOR DEVELOPMENT AND COEXISTENT RENAL CELL CARCINOMA The Journal of Urology. ,vol. 162, pp. 40- 42 ,(1999) , 10.1097/00005392-199907000-00010
Tomas Gudbjartsson, Sverrir Hardarson, Vigdis Petursdottir, Asgeir Thoroddsen, Jonas Magnusson, Gudmundur V. Einarsson, Renal oncocytoma: a clinicopathological analysis of 45 consecutive cases. BJUI. ,vol. 96, pp. 1275- 1279 ,(2005) , 10.1111/J.1464-410X.2005.05827.X
Neil A. Abrahams, Pheroze Tamboli, Oncocytic renal neoplasms: diagnostic considerations. Clinics in Laboratory Medicine. ,vol. 25, pp. 317- 339 ,(2005) , 10.1016/J.CLL.2005.01.006
Leo Romis, Luca Cindolo, Jean Jacques Patard, Giovanni Messina, Vincenzo Altieri, Laurent Salomon, Claude Clement Abbou, Dominique Chopin, Bernard Lobel, Alexandre de La Taille, Frequency, clinical presentation and evolution of renal oncocytomas: multicentric experience from a European database. European Urology. ,vol. 45, pp. 53- 57 ,(2004) , 10.1016/J.EURURO.2003.08.008