Ebselen Decreases Oxygen Free Radical Production and Iron Concentrations in the Hearts of Chronically Iron-Overloaded Mice:

摘要: Chronic iron overload is a major cause of cardiac failure throughout the world, but its pathogenesis remains to be clarified. It conjectured that toxicity due ability catalyze formation oxygen free radicals (OFR), which can damage cellular membranes, proteins, and DNA. The authors report on cardioprotective effects glutathione peroxidase (GPx) mimic ebselen concentrations in heart GPx activity, production cytotoxic aldehydes hexanal, 4-hydroxyl-2-nonenal (HNE), malondialdehyde (MDA). Fifteen B6D2F1 mice were randomized 1 3 treatment groups for total 20 treatments: 1) control (0.1 mL normal saline i.p. per mouse, day); 2) iron-only (10 mg dextran 3) plus (25 mg/kg p.o. day). In comparison treated mice, authors' findings show supplementation with decrease both aldehyde tissue. Additionally, supplemented had an increase activity level mice. To knowledge, this first study examine against OFR model chronic overload. These suggest may have significance management disorders