Effect of Ebselen on Renal Scarring in Rats following Renal Infection

摘要: Renal scarring, which occurs following refluxing pyelonephritis, is considered to be involved in the development of reflux nephropathy. Prevention renal scar formation requires immediate initiation antimicrobial treatment; treatment delay results scarring. We demonstrate that Ebselen, an antioxidant agent, given at a dose 15 mg/kg twice day prevents scarring rats direct parenchymal bacterial inoculation. In addition, using ascending pyelonephritis model, clinically resembles humans, we show when was delayed, coadministration Ebselen formation. These effective preventing and suggest clinical use this drug may prevent progression