The effect of vitamin A on renal damage following acute pyelonephritis in children.

作者: Parviz Ayazi , Seyed Alireza Moshiri , Abolfazl Mahyar , Mona Moradi

DOI: 10.1007/S00431-010-1297-1

关键词:

摘要: Animal studies suggest that administration of vitamin A to rats with experimental urinary tract infection decreases the frequency renal scars (Kavukcu et al., BJU Int 83(9):1055–1059, 1999). The aim this study was determine effect on rate permanent damage in children acute pyelonephritis. Fifty children, median age 24 months (range 2–144), first-time pyelonephritis verified by an uptake defect dimercaptosuccinic acid (DMSA) scan were included and randomly allocated case or control groups. All given intravenous ceftriaxone for 10 days followed oral cephalexin 3 months. Cases addition a single intramuscular dose A, 25,000 U infants below 1 year 50,000 older children. At repeat DMSA after months, five 25 cases (20%) 17 controls (68%) had abnormal findings (p = 0.001). In conclusion, associated significantly lower damage.

参考文章(23)
Kavukçu, Soylu, Türkmen, Sarioglu, Büyükgebiz, Güre, The role of vitamin A in preventing renal scarring secondary to pyelonephritis BJUI. ,vol. 83, pp. 1055- 1059 ,(2001) , 10.1046/J.1464-410X.1999.00063.X
Hal B. Jenson, [edited by] Richard E. Behrman, Robert M. Kliegman, Nelson textbook of pediatrics ,(1945)
Masashi Haraoka, Tetsuro Matsumoto, Yoshimitsu Mizunoe, Koichi Takahashi, Shuta Kubo, Yasuhiro Koikawa, Masatoshi Tanaka, Yasuki Sakamoto, Misao Sakumoto, Tatsuo Nagafuji, Joichi Kumazawa, Effect of Ebselen on Renal Scarring in Rats following Renal Infection Chemotherapy. ,vol. 41, pp. 208- 213 ,(1995) , 10.1159/000239346
Zhina Sadeghi, Abdol-Mohammad Kajbafzadeh, Parvin Tajik, Maryam Monajemzadeh, Seyedmehdi Payabvash, Azadeh Elmi, None, Vitamin E administration at the onset of fever prevents renal scarring in acute pyelonephritis. Pediatric Nephrology. ,vol. 23, pp. 1503- 1510 ,(2008) , 10.1007/S00467-008-0853-7
Salih Kavukcu, Mehmet Atilla Turkmen, Alper Soylu, Could the effective mechanisms of retinoids on nephrogenesis be also operative on the amelioration of injury in acquired renal lesions Pediatric Nephrology. ,vol. 16, pp. 689- 690 ,(2001) , 10.1007/S004670100606
Su Cho, Seung Lee, ACE gene polymorphism and renal scar in children with acute pyelonephritis. Pediatric Nephrology. ,vol. 17, pp. 491- 495 ,(2002) , 10.1007/S00467-002-0902-6
F. Bouissou, C. Munzer, S. Decramer, B. Roussel, R. Novo, D. Morin, M. P. Lavocat, C. Guyot, S. Taque, M. Fischbach, E. Ouhayoun, C. Loirat, , , Prospective, randomized trial comparing short and long intravenous antibiotic treatment of acute pyelonephritis in children: dimercaptosuccinic acid scintigraphic evaluation at 9 months. Pediatrics. ,vol. 121, ,(2008) , 10.1542/PEDS.2006-3632
Mustafa İmamoğlu, Ali Cay, Ümit Çobanoglu, Elif Bahat, Caner Karahan, Ilknur Tosun, Haluk Sarıhan, Effects of melatonin on suppression of renal scarring in experimental model of pyelonephritis Urology. ,vol. 67, pp. 1315- 1319 ,(2006) , 10.1016/J.UROLOGY.2005.12.013
Chris L. Kjolhede, Francisco J. Chew, Anne M. Gadomski, Diana P. Marroquin, Clinical trial of vitamin A as adjuvant treatment for lower respiratory tract infections The Journal of Pediatrics. ,vol. 126, pp. 807- 812 ,(1995) , 10.1016/S0022-3476(95)70416-7