The role of vitamin A in preventing renal scarring secondary to pyelonephritis

摘要: Objective To evaluate the efficiency of exogenously administered vitamin A in preventing renal scarring caused by experimental pyelonephritis rats. Materials and methods Forty Wistar rats were injected with 0.1 mL solution containing Escherichia coli (1010 /mL) into both medullae. Five equal groups then formed: group 1 was treated only ciprofloxacin (30 mg/kg per day, twice daily, intraperitoneally) for 5 days, starting 3 days after bacterial inoculation; 2, 60 kIU intramuscularly 3, similarly, but 4, given orally from third day inoculation. All killed 6 weeks injection; blood samples obtained to determine serum β-carotene levels, kidneys examined pathologically scarring, graded as 0 (none), (mild), 2 (moderate) (severe). Results Serum levels higher (group 2–5) than 1, being highest although this had significantly (P<0.05). Histopathologically, fibrosis mildest 4 (two 16 grade 1), whereas it most severe (all 2–3). Fibrosis less 2–5 There a significant negative correlation between sum fibrosis, inflammation tubular atrophy scores all (r=−0.391, P<0.02). unrelated scarring. Conclusion The administration could have role scar formation induced experimentally rats.