CYTOKINE GENE EXPRESSION DURING EXPERIMENTAL ESCHERICHIA COLI PYELONEPHRITIS IN MICE
作者： Adli Khalil , Annelie Brauner , Moiz Bakhiet , Lars G. Burman , Georg Jaremko
DOI: 10.1016/S0022-5347(01)64282-4
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摘要: ABSTRACTPurpose: We studied nine inflammatory and immunoregulatory cytokines in acute pyelonephritis urethral obstruction mice to better understand the processes underlying kidney inflammation scarring.Materials Methods: Experimental was established Bki NMRI outbred by bladder inoculation of Escherichia coli, followed 6 h obstruction. The numbers cytokine mRNA expressing cells for interleukin-1 (IL-1), IL-4, IL-6, IL-10, IL-12, tumor necrosis factor alpha (TNF-alpha), TNF-beta, transforming growth beta (TGF-beta) interferon gamma (IFN-gamma) were determined kidneys spleens from infected, non-infected but obstructed untouched using situ hybridization with radio-labelled oligonucleotide probes at 12 h, 48 d after release obstruction.Results: Kidney cell expression IL-1, IL-6 TNF-alpha observed already persisted on day infected animals. A significant pr...
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jurology.com 参考文章(30)
K. Moore, P Vieira, D. Fiorentino, M. Trounstine, T. Khan, T. Mosmann, Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI. Science. ,vol. 248, pp. 1230- 1234 ,(1990) , 10.1126/SCIENCE.2161559
M. P. Glauser, P. Meylan, J. Bille, The inflammatory response and tissue damage. The example of renal scars following acute renal infection. Pediatric Nephrology. ,vol. 1, pp. 615- 622 ,(1987) , 10.1007/BF00853599
�. Dagerlind, K. Friberg, A. J. Bean, T. H�kfelt, Sensitive mRNA detection using unfixed tissue: combined radioactive and non-radioactive in situ hybridization histochemistry Histochemistry and Cell Biology. ,vol. 98, pp. 39- 49 ,(1992) , 10.1007/BF00716936
K Tullus, R Escobar-Billing, O Fituri, LG Burman, A Karlsson, I Wikstad, B Wretlind, A Brauner, Interleukin-1α and interleukin-1 receptor antagonist in the urine of children with acute pyelonephritis and relation to renal scarring Acta Paediatrica. ,vol. 85, pp. 158- 162 ,(1996) , 10.1111/J.1651-2227.1996.TB13984.X
Kjell Tullus, Ji-an Wang, Ying Lu, Lars G. Burman, Annelie Brauner, Interleukin-1&; and interleukin-6 in the urine, kidney, and bladder of mice inoculated with Escherichia coli Pediatric Nephrology. ,vol. 10, pp. 453- 457 ,(1996) , 10.1007/S004670050138
C Gérard, C Bruyns, A Marchant, D Abramowicz, P Vandenabeele, A Delvaux, W Fiers, M Goldman, T Velu, Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia. Journal of Experimental Medicine. ,vol. 177, pp. 547- 550 ,(1993) , 10.1084/JEM.177.2.547
D Islam, P K Bardhan, A A Lindberg, B Christensson, Shigella infection induces cellular activation of T and B cells and distinct species-related changes in peripheral blood lymphocyte subsets during the course of the disease. Infection and Immunity. ,vol. 63, pp. 2941- 2949 ,(1995) , 10.1128/IAI.63.8.2941-2949.1995
Andrew J. McKnight, A. Neil Barclay, Don W. Mason, Molecular cloning of rat interleukin 4 cDNA and analysis of the cytokine repertoire of subsets of CD4+ T cells. European Journal of Immunology. ,vol. 21, pp. 1187- 1194 ,(1991) , 10.1002/EJI.1830210514
D E Johnson, R G Russell, C V Lockatell, J C Zulty, J W Warren, Urethral obstruction of 6 hours or less causes bacteriuria, bacteremia, and pyelonephritis in mice challenged with "nonuropathogenic" Escherichia coli. Infection and Immunity. ,vol. 61, pp. 3422- 3428 ,(1993) , 10.1128/IAI.61.8.3422-3428.1993
Franklin H. Epstein, Wayne A. Border, Nancy A. Noble, Transforming Growth Factor β in Tissue Fibrosis New England Journal of Medicine. ,vol. 331, pp. 1286- 1292 ,(1994) , 10.1056/NEJM199411103311907