Blockade of Rennin-Angiotensin system blunts the fibrotic response in experimental acute pyelonephritis

摘要: Aim: To study the impact of Renin-Angiotensin system blockade in experimental acute pyelonephritis, induced by a novel surgical approach via dorsal lumbotomy incision. Materials and Methods : 45 Adult female WISTAR rats aged 8-12 weeks, underwent direct inoculation 0.1 ml E.coli suspension into parenchyma surgically exposed kidney. 3 groups were studied: Group A - treated with antibiotics only; B- Captopril C- Losartan antibiotics. Changes inflammation, parenchymal destruction scarring compared between on histopathological sections. Kruskal-Wallis test was used for statistical analysis. Results consistent pyelonephritis seen all kidneys. Mean% scar area A, B C 37.08±1.79, 24.40±1.88 24.68±1.32% respectively at end six weeks. Mean tubular density 17.26±1.92, 47.18±3.00 47.00±5.08-tubules/lac mm2 respectively. The differences control animals significant, though results did not differ losartan captopril rats. Conclusions Dorsal to kidney provides good exposure Induction bacteria renal cortex produced 6 Blockade renin angiotensin either or decreased almost 1/3