Dimerization of TCTP and its clinical implications for allergy

摘要: Following the detection of histamine-releasing activity (HRA) in supernatants peripheral blood mononuclear cell cultures, research efforts were directed at characterizing source this activity, mostly focusing, on IgE-dependent factors (HRFs). HRF is now variously called translationally controlled tumor protein (TCTP), p21, p23, and fortilin. TCTP exhibits cytokine-like functions including release histamine, induction TH2 cytokines chemoattractants, augmentation B proliferation, immunoglobulin production during late phase allergic inflammation. Because its association with status patients, emerged as a potential key agent modulation diseases. Several lines evidence suggest that only after it modified by proteases, altered oxidant-antioxidant balance E, present inflamed sites. This review will try to show dimerization critical modification if not modification, responsible for causing