P300 and LORETA: comparison of normal subjects and schizophrenic patients.

摘要: It was the aim of present study 1) to investigate how many cortical activity maxima scalp-recorded P300 are detected by Low Resolution Electromagentic Tomography (LORETA) when analyses performed with high time-resolution, 2) see if resulting LORETA-solution is in accordance intracortical recordings as reported others and 3) compare given pattern activation P300-timeframe between schizophrenic patients normal controls. Current density analysis 3-D Talairach space time resolution i.e. 6 ms steps. This done during an auditory choice reaction paradigm separately for subjects subsequent group comparisons. In subjects, a sequence at least seven found 240-420ms poststimulus: prefrontal cortex, anterior or medial cingulum, posterior parietal temporal lobe, cingulum. Within limits spatial resolution, this sequential distribution largely met expectations from reports on intracranial functional neuroimaging studies. However, localization accuracy higher near central midline than lateral aspects brain. Schizophrenic less activated their cortex widespread area mainly left hemisphere including cingulum lobe. From these comparsions others, it concluded that LORETA correctly localizes P300-related basis 19 electrodes except which most likely edge-phenomenon. The data further suggest P300-deficit schizophrenics involves extended network several steps information processing stream.