P300 amplitude is related to clinical state in severely and moderately ill patients with schizophrenia

摘要: Abstract Background: Relationships between illness severity and neurobiologic abnormalities in schizophrenia were studied subpopulations varying clinical severity. Methods: Auditory ERPs collected from 28 severely ill, chronically hospitalized schizophrenic men a state hospital; 29 moderately ill inpatient outpatient veterans 30 healthy male subjects the community as controls. Clinical symptoms evaluated patients using Brief Psychiatric Rating Scale (BPRS). Results: Both patient groups had smaller P300 amplitude than control subjects. Severely P300s scored higher on three BPRS factor scores well Total. Among patients, was unrelated to symptoms. related Withdrawal/Retardation, Anxiety/Depression, After combining Thinking Disturbance emerged an additional correlate of P300. Group differences could not be accounted for by group symptom analysis covariance. Conclusions: Reduced marks diagnosis schizophrenia, but also reflects individual severity, including positive Previous failures find relationships may have been due restricted range