Testosterone and estradiol regulate free insulin-like growth factor I (IGF-I), IGF binding protein 1 (IGFBP-1), and dimeric IGF-I/IGFBP-1 concentrations.
作者： Johannes D. Veldhuis , Jan Frystyk , Ali Iranmanesh , Hans Ørskov
DOI: 10.1210/JC.2004-1314
关键词: Androgen 、 Saline 、 Estrogen 、 Biology 、 Crossover study 、 Insulin-like growth factor-binding protein 、 Testosterone 、 Endocrinology 、 Binding protein 、 Growth factor 、 Internal medicine
摘要: The present study tests the clinical postulate that elevated testosterone (Te) and estradiol (E2) concentrations modulate effects of constant iv infusion saline vs. recombinant human IGF-I on free IGF-I, IGF binding protein (IGFBP)-1, dimeric IGF-I/IGFBP-1 in healthy aging adults. To this end, comparisons were made after administration placebo (Pl) Te eight older men (aged 61 ± 4 yr) Pl E2 postmenopausal women (62 3 yr). In session, lowered increased total IGF-I; specifically IGFBP-1 by 1.5-fold suppressed 34%; binary 5-fold more than Te. During infusion, following found: 1) rose 1.4- to 2.0-fold 2.1–2.5-fold rapidly women; 2) 3.4-fold (E2); 3) end-infusion was 1.6-fold higher women. summary, E2, comp...
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