Colitogenic Th1 Cells Are Present in the Antigen-Experienced T Cell Pool in Normal Mice: Control by CD4+ Regulatory T Cells and IL-10

摘要: CD4(+) regulatory T cells have been shown to prevent intestinal inflammation; however, it is not known whether they act the priming of colitogenic or actively control these as part memory cell pool. In this study, we describe presence Th1 within CD4(+)CD45RB(low) population. These pathogenic enrich CD25(-) subset and are recent thymic emigrants. from germfree mice were significantly reduced in their ability transfer colitis immune deficient recipients, suggesting commensal bacteria donor drives into Ag-experienced/memory This potentially population Ag-experienced subject cell-mediated regulation vivo by both CD4(+)CD25(+) CD4(+)CD25(-) an IL-10-dependent manner. Furthermore, administration anti-IL-10R mAb unmanipulated adult was sufficient induce development colitis. Taken together, data indicate that enter pool normal mice, but function controlled IL-10. Interestingly, IL-10 absolutely required for inhibition induced naive CD4(+)CD45RB(high) cells, a differential requirement cells.