Ixorapeptide I and ixorapeptide II, bioactive peptides isolated from Ixora coccinea

摘要: Two novel derivatized peptides, designated as ixorapeptide I (1) and II (2), in addition to 28 other known compounds, were isolated from the MeOH extract of Ixora coccinea using bioassay-guided fractionation. The structures metabolites 1 2 determined by interpretation spectroscopic data Marfey's method. Compound exhibited selective potency against Hep3B liver cancer cell line with an IC(50) value 3.36 μg/mL, compound did not show notable cytotoxicity toward lines but could inhibit superoxide anion generation elastase release values 0.21 0.27 respectively. Moreover, kaempferol luteolin this plant showed inhibition 3.55 2.56 respectively on platelet aggregation induced collagen.