Rate-limiting steps in carcinogenesis and their bearing on the incidence/age data for cutaneous melanoma and hepatocellular carcinoma

摘要: We analyze published data on cancer incidence as a function of age for (i) cutaneous melanoma cohorts males in Connecticut and (ii) hepatocellular Mozambique, China Romania, the basis multi-hit models carcinogenesis. The simple model suggests an unlikely scenario which, advance or intensity mutagenesis increases, fewer mutations are required to bring about appearance cancer. present new version which two sets mutatable loci present, differing sensitivities mutagens. This provides more acceptable description number rate-limiting steps drops frequency mutation rises, so that some these no longer rate-limiting.